Insulin binding to circulating monocytes and erythrocytes in patients with non-insulin-dependent diabetes in the young

C. Naidoo, I. Jialal, R. D. Dunn, T. Govender, S. M. Joubert

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Abstract

125I-insulin binding to circulating monocytes and erythrocytes was carried out in 9 patients with non-insulin-dependent diabetes in the young (NIDDY), who belonged to families in which non-insulin-dependent diabetes was transmitted through 3 generations. The diabetics had a decreased mean maximum specific binding to monocytes 2.1 (1.1-4.1%) compared to 4.0 (2.6-6.2%) in their age, sex and weight matched reference subjects. This decreased binding was primarily due to a decrease in receptor number as all diabetics had normal affinity values (2-10 ng/ml). We have attributed the decreased binding in NIDDY to the down regulatory effect of the basal hyperinsulinemia (23.6 ± 3.2 vs 11.7 ± 0.5 μU/ml). By contrast the maximum specific binding to erythrocyte was similar in both groups (9.7 ± 0.5; 8.9 ± 0.5%; p > 0.5).

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalDiabetes Research
Volume4
Issue number1
StatePublished - 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Naidoo, C., Jialal, I., Dunn, R. D., Govender, T., & Joubert, S. M. (1987). Insulin binding to circulating monocytes and erythrocytes in patients with non-insulin-dependent diabetes in the young. Diabetes Research, 4(1), 35-38.