Abstract
125I-insulin binding to circulating monocytes and erythrocytes was carried out in 9 patients with non-insulin-dependent diabetes in the young (NIDDY), who belonged to families in which non-insulin-dependent diabetes was transmitted through 3 generations. The diabetics had a decreased mean maximum specific binding to monocytes 2.1 (1.1-4.1%) compared to 4.0 (2.6-6.2%) in their age, sex and weight matched reference subjects. This decreased binding was primarily due to a decrease in receptor number as all diabetics had normal affinity values (2-10 ng/ml). We have attributed the decreased binding in NIDDY to the down regulatory effect of the basal hyperinsulinemia (23.6 ± 3.2 vs 11.7 ± 0.5 μU/ml). By contrast the maximum specific binding to erythrocyte was similar in both groups (9.7 ± 0.5; 8.9 ± 0.5%; p > 0.5).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-38 |
| Number of pages | 4 |
| Journal | Diabetes Research |
| Volume | 4 |
| Issue number | 1 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Insulin binding to circulating monocytes and erythrocytes in patients with non-insulin-dependent diabetes in the young. / Naidoo, C.; Jialal, I.; Dunn, R. D.; Govender, T.; Joubert, S. M.
In: Diabetes Research, Vol. 4, No. 1, 1987, p. 35-38.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin binding to circulating monocytes and erythrocytes in patients with non-insulin-dependent diabetes in the young
AU - Naidoo, C.
AU - Jialal, I.
AU - Dunn, R. D.
AU - Govender, T.
AU - Joubert, S. M.
PY - 1987
Y1 - 1987
N2 - 125I-insulin binding to circulating monocytes and erythrocytes was carried out in 9 patients with non-insulin-dependent diabetes in the young (NIDDY), who belonged to families in which non-insulin-dependent diabetes was transmitted through 3 generations. The diabetics had a decreased mean maximum specific binding to monocytes 2.1 (1.1-4.1%) compared to 4.0 (2.6-6.2%) in their age, sex and weight matched reference subjects. This decreased binding was primarily due to a decrease in receptor number as all diabetics had normal affinity values (2-10 ng/ml). We have attributed the decreased binding in NIDDY to the down regulatory effect of the basal hyperinsulinemia (23.6 ± 3.2 vs 11.7 ± 0.5 μU/ml). By contrast the maximum specific binding to erythrocyte was similar in both groups (9.7 ± 0.5; 8.9 ± 0.5%; p > 0.5).
AB - 125I-insulin binding to circulating monocytes and erythrocytes was carried out in 9 patients with non-insulin-dependent diabetes in the young (NIDDY), who belonged to families in which non-insulin-dependent diabetes was transmitted through 3 generations. The diabetics had a decreased mean maximum specific binding to monocytes 2.1 (1.1-4.1%) compared to 4.0 (2.6-6.2%) in their age, sex and weight matched reference subjects. This decreased binding was primarily due to a decrease in receptor number as all diabetics had normal affinity values (2-10 ng/ml). We have attributed the decreased binding in NIDDY to the down regulatory effect of the basal hyperinsulinemia (23.6 ± 3.2 vs 11.7 ± 0.5 μU/ml). By contrast the maximum specific binding to erythrocyte was similar in both groups (9.7 ± 0.5; 8.9 ± 0.5%; p > 0.5).
UR - http://www.scopus.com/inward/record.url?scp=0023240425&partnerID=8YFLogxK
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M3 - Article
VL - 4
SP - 35
EP - 38
JO - Diabetes Research
JF - Diabetes Research
SN - 0265-5985
IS - 1
ER -