Abstract
125I-insulin binding to circulating monocytes and erythrocytes was carried out in 9 patients with non-insulin-dependent diabetes in the young (NIDDY), who belonged to families in which non-insulin-dependent diabetes was transmitted through 3 generations. The diabetics had a decreased mean maximum specific binding to monocytes 2.1 (1.1-4.1%) compared to 4.0 (2.6-6.2%) in their age, sex and weight matched reference subjects. This decreased binding was primarily due to a decrease in receptor number as all diabetics had normal affinity values (2-10 ng/ml). We have attributed the decreased binding in NIDDY to the down regulatory effect of the basal hyperinsulinemia (23.6 ± 3.2 vs 11.7 ± 0.5 μU/ml). By contrast the maximum specific binding to erythrocyte was similar in both groups (9.7 ± 0.5; 8.9 ± 0.5%; p > 0.5).
Original language | English (US) |
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Pages (from-to) | 35-38 |
Number of pages | 4 |
Journal | Diabetes Research |
Volume | 4 |
Issue number | 1 |
State | Published - 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology
- Internal Medicine
- Endocrinology, Diabetes and Metabolism