Instrument for measurement of singlet oxygen for studies of skin under UVA irradiation

S. J. Davis, D. I. Rosen, J. England, M. F. Hinds, Raja K Sivamani, W. Burney

Research output: Contribution to journalConference article

Abstract

In this paper we will describe a non-intrusive, optically-based instrument that can quantitatively measure singlet molecular oxygen, a constituent of reactive oxygen species (ROS) produced by irradiation of human skin by the longer wavelength UV radiation known as UVA. UVA is causally associated with DNA damage and subsequent development of melanoma. We will present data from healthy human subjects that show formation of singlet molecular oxygen and concomitant production of thymine dimers, indicative of DNA damage. We will also discuss how this instrument may be a valuable tool for the development of more effective sunblock formulations for UVA.

Original languageEnglish (US)
Article number108510J
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10851
DOIs
StatePublished - Jan 1 2019
EventPhotonics in Dermatology and Plastic Surgery 2019 - San Francisco, United States
Duration: Feb 2 2019Feb 3 2019

Fingerprint

Singlet Oxygen
Molecular oxygen
DNA Damage
Skin
DNA
deoxyribonucleic acid
Irradiation
oxygen production
damage
Pyrimidine Dimers
irradiation
Oxygen
thymine
oxygen
Ultraviolet radiation
Dimers
Melanoma
Reactive Oxygen Species
Healthy Volunteers
dimers

Keywords

  • Reactive oxygen species
  • Singlet oxygen
  • Skin damage
  • Ultraviolet solar radiation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Instrument for measurement of singlet oxygen for studies of skin under UVA irradiation. / Davis, S. J.; Rosen, D. I.; England, J.; Hinds, M. F.; Sivamani, Raja K; Burney, W.

In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 10851, 108510J, 01.01.2019.

Research output: Contribution to journalConference article

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