Insights from genomic profiling of transcription factors

Peggy J. Farnham

Research output: Contribution to journalArticle

373 Scopus citations

Abstract

A crucial question in the field of gene regulation is whether the location at which a transcription factor binds influences its effectiveness or the mechanism by which it regulates transcription. Comprehensive transcription factor binding maps are needed to address these issues, and genome-wide mapping is now possible thanks to the technological advances of ChIP-chip and ChIP-seq. This Review discusses how recent genomic profiling of transcription factors gives insight into how binding specificity is achieved and what features of chromatin influence the ability of transcription factors to interact with the genome. It also suggests future experiments that may further our understanding of the causes and consequences of transcription factor-genome interactions.

Original languageEnglish (US)
Pages (from-to)605-616
Number of pages12
JournalNature Reviews Genetics
Volume10
Issue number9
DOIs
StatePublished - Sep 2009

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

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