Insertional activation of c-myc by reticuloendotheliosis virus in chicken B lymphoma

Nonrandom distribution and orientation of the proviruses

R. A. Swift, E. Shaller, R. L. Witter, Hsing-Jien Kung

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Chicken syncytial virus, a member of the reticuloendotheliosis virus family, can induce chicken B lymphomas indistinguishable from those caused by avian leukosis virus. Previously, we have demonstrated that the chicken syncytial virus proviruses in these tumors are linked to the proto-oncogene c-myc. We have now determined the arrangement of chicken syncytial virus proviruses in 22 tumors. The results indicate that these proviruses, without exception, are integrated upstream from the second c-myc exon. At least 70% of these insertion sites are clustered in a 0.5-kilobase region immediately preceding the exon. The proviruses are all arranged in the same transcriptional orientation as c-myc. This type of provirus organization bears strong resemblance to that of the avian leukosis virus proviruses involved in c-myc activation.

Original languageEnglish (US)
Pages (from-to)869-872
Number of pages4
JournalJournal of Virology
Volume54
Issue number3
StatePublished - 1985
Externally publishedYes

Fingerprint

Reticuloendotheliosis virus
proviruses
Proviruses
Insertional Mutagenesis
lymphoma
Chickens
Lymphoma
chickens
Avian Leukosis Virus
Avian leukosis virus
Viruses
viruses
exons
Exons
proto-oncogenes
myc Genes
neoplasms
Neoplasms

ASJC Scopus subject areas

  • Immunology

Cite this

Insertional activation of c-myc by reticuloendotheliosis virus in chicken B lymphoma : Nonrandom distribution and orientation of the proviruses. / Swift, R. A.; Shaller, E.; Witter, R. L.; Kung, Hsing-Jien.

In: Journal of Virology, Vol. 54, No. 3, 1985, p. 869-872.

Research output: Contribution to journalArticle

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