Insecticidal effects of an insect-specific neurotoxin expressed by a recombinant baculovirus

Susumu Maeda, Sandra L. Volrath, Terry N. hanzlik, S. Andrew Harper, Kei Majima, Daryl W. Maddox, Bruce D. Hammock, Elizabeth Fowler

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


The scorpion Androctonus austrafis has a peptide (AaIT) which selectively targets the insect sodium channel. This mode of action is similar to that of many widely used chemical insecticides. When Bombyx mori larvae were infected with a recombinant baculovirus carrying a synthetic MIT gene, the expressed protein was secreted into the hemolymph and caused symptoms consistent with sodium channel blocking, including tremors and feeding cessation at 40 hr p.i. followed by paralysis and death by 60 hr p.i. Larvae infected with control virus died by 96 hr p.i. These results indicate that foreign genes can be used in recombinant baculoviruses to reduce insect feeding damage and increase the rate of insect kill.

Original languageEnglish (US)
Pages (from-to)777-780
Number of pages4
Issue number2
StatePublished - 1991

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


Dive into the research topics of 'Insecticidal effects of an insect-specific neurotoxin expressed by a recombinant baculovirus'. Together they form a unique fingerprint.

Cite this