Abstract
The uptake of radiolabeled myo-inositol by Schwann cells isolated from the sciatic nerve of 2-4 day old rats was found to occur by a saturable, sodium-dependent phlorizin-inhibited mechanism with an estimated Km of 30μM. The system was inhibited by galactose and glucose but not by galactitol. At high concentrations of myo-inositol, a diffusion-like process appeared to be functional. The characteristics of the saturable system are very similar to those of myo-inositol uptake by the endoneural fascicle preparation of sciatic nerve.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 486-492 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 120 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 30 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Cite this
Segal, S., Hwang, S. M., Stern, J., & Pleasure, D. E. (1984). Inositol uptake by cultured isolated rat Schwann cells. Biochemical and Biophysical Research Communications, 120(2), 486-492. https://doi.org/10.1016/0006-291X(84)91280-4