Inositol uptake by cultured isolated rat Schwann cells

Stanton Segal; Shing Mei Hwang; Janet Stern; David E Pleasure

doi:10.1016/0006-291X(84)91280-4

Inositol uptake by cultured isolated rat Schwann cells

Stanton Segal, Shing Mei Hwang, Janet Stern, David E Pleasure

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The uptake of radiolabeled myo-inositol by Schwann cells isolated from the sciatic nerve of 2-4 day old rats was found to occur by a saturable, sodium-dependent phlorizin-inhibited mechanism with an estimated K_m of 30μM. The system was inhibited by galactose and glucose but not by galactitol. At high concentrations of myo-inositol, a diffusion-like process appeared to be functional. The characteristics of the saturable system are very similar to those of myo-inositol uptake by the endoneural fascicle preparation of sciatic nerve.

Original language	English (US)
Pages (from-to)	486-492
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	120
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(84)91280-4
State	Published - Apr 30 1984
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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title = "Inositol uptake by cultured isolated rat Schwann cells",

abstract = "The uptake of radiolabeled myo-inositol by Schwann cells isolated from the sciatic nerve of 2-4 day old rats was found to occur by a saturable, sodium-dependent phlorizin-inhibited mechanism with an estimated Km of 30μM. The system was inhibited by galactose and glucose but not by galactitol. At high concentrations of myo-inositol, a diffusion-like process appeared to be functional. The characteristics of the saturable system are very similar to those of myo-inositol uptake by the endoneural fascicle preparation of sciatic nerve.",

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AU - Segal, Stanton

AU - Hwang, Shing Mei

AU - Stern, Janet

AU - Pleasure, David E

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Y1 - 1984/4/30

N2 - The uptake of radiolabeled myo-inositol by Schwann cells isolated from the sciatic nerve of 2-4 day old rats was found to occur by a saturable, sodium-dependent phlorizin-inhibited mechanism with an estimated Km of 30μM. The system was inhibited by galactose and glucose but not by galactitol. At high concentrations of myo-inositol, a diffusion-like process appeared to be functional. The characteristics of the saturable system are very similar to those of myo-inositol uptake by the endoneural fascicle preparation of sciatic nerve.

AB - The uptake of radiolabeled myo-inositol by Schwann cells isolated from the sciatic nerve of 2-4 day old rats was found to occur by a saturable, sodium-dependent phlorizin-inhibited mechanism with an estimated Km of 30μM. The system was inhibited by galactose and glucose but not by galactitol. At high concentrations of myo-inositol, a diffusion-like process appeared to be functional. The characteristics of the saturable system are very similar to those of myo-inositol uptake by the endoneural fascicle preparation of sciatic nerve.

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