Inositol uptake by cultured isolated rat Schwann cells

Stanton Segal, Shing Mei Hwang, Janet Stern, David E Pleasure

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The uptake of radiolabeled myo-inositol by Schwann cells isolated from the sciatic nerve of 2-4 day old rats was found to occur by a saturable, sodium-dependent phlorizin-inhibited mechanism with an estimated Km of 30μM. The system was inhibited by galactose and glucose but not by galactitol. At high concentrations of myo-inositol, a diffusion-like process appeared to be functional. The characteristics of the saturable system are very similar to those of myo-inositol uptake by the endoneural fascicle preparation of sciatic nerve.

Original languageEnglish (US)
Pages (from-to)486-492
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume120
Issue number2
DOIs
StatePublished - Apr 30 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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