Inositol 1,4,5-trisphosphate receptors as signal integrators

Randen L. Patterson, Darren Boehning, Solomon H. Snyder

Research output: Contribution to journalArticle

351 Citations (Scopus)

Abstract

The inositol 1,4,5 trisphosphate (IP3) receptor (IP 3R) is a Ca2+ release channel that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+ release via IP3Rs is achieved by the ability of IP3R to integrate signals from numerous small molecules and proteins including nucleotides, kinases, and phosphatases, as well as nonenzyme proteins. Because the ion conduction pore composes only ∼5% of the IP3R, the great bulk of this large protein contains recognition sites for these substances. Through these regulatory mechanisms, IP3R modulates diverse cellular functions, which include, but are not limited to, contraction/excitation, secretion, gene expression, and cellular growth. We review the unique properties of the IP3R that facilitate cell-type and stimulus-dependent control of function, with special emphasis on protein-binding partners.

Original languageEnglish (US)
Pages (from-to)437-465
Number of pages29
JournalAnnual Review of Biochemistry
Volume73
DOIs
StatePublished - 2004
Externally publishedYes

Fingerprint

Inositol 1,4,5-Trisphosphate Receptors
Inositol 1,4,5-Trisphosphate
Phosphoprotein Phosphatases
Second Messenger Systems
Gene expression
Proteins
Phosphotransferases
Nucleotides
Modulation
Ions
Phosphoric Monoester Hydrolases
Protein Binding
Molecules
Gene Expression
Growth

Keywords

  • Calcium
  • Entry
  • Kinases
  • Regulation
  • Release
  • Scaffold
  • Structure

ASJC Scopus subject areas

  • Biochemistry

Cite this

Inositol 1,4,5-trisphosphate receptors as signal integrators. / Patterson, Randen L.; Boehning, Darren; Snyder, Solomon H.

In: Annual Review of Biochemistry, Vol. 73, 2004, p. 437-465.

Research output: Contribution to journalArticle

Patterson, Randen L. ; Boehning, Darren ; Snyder, Solomon H. / Inositol 1,4,5-trisphosphate receptors as signal integrators. In: Annual Review of Biochemistry. 2004 ; Vol. 73. pp. 437-465.
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