Inorganic agricultural dust exposure causes pneumoconiosis among farmworkers

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Early studies of agricultural respiratory diseases focused on allergic disorders due to organic dust exposure. However, agricultural workers in dry climate regions are exposed to substantial concentrations of inorganic dusts from agricultural soils. Exposures to inorganic dusts are dependent on the specific crop and task, but are commonly several milligrams of respirable dust per cubic millimeter. In vitro toxicity studies show the dust's cytotoxicity to be intermediate between controls and crystalline silica. However, in some assays of reactive oxygen species generation, such as H2O2, hydroxyl radical, and nuclear factor κB generation, the agricultural dusts are more potent than silica. A recent study of human lung samples among deceased Latino males characterized the deposition of agricultural dusts in the lung and the pulmonary response to these dusts. Careful histologic analyses in this study demonstrated that farmwork was significantly associated with mineral dust small airways disease and pneumoconiosis (macules and/or nodules). These associations persisted in multivariate analysis. Cigarette smoking was independently associated with these outcomes, but the interaction of mineral dust and smoking was not significant. Limited studies of farmworkers exposed to inorganic dusts show respiratory symptoms and restrictive pulmonary function with exposure. Overall, the evidence supports a causal association of mineral dust exposure and pneumoconiosis. Inorganic mineral dusts should no longer be considered merely a nuisance, but rather a cause of mixed-dust pneumoconiosis. The prevalence and natural history of this disorder are unknown.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalProceedings of the American Thoracic Society
Volume7
Issue number2
DOIs
StatePublished - May 1 2010

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Pneumoconiosis
Dust
Minerals
Lung
Farmers
Silicon Dioxide
Smoking
Natural History
Climate
Hispanic Americans
Hydroxyl Radical

Keywords

  • Farmworkers
  • Inorganic dust
  • Pneumoconiosis
  • Toxicology

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Inorganic agricultural dust exposure causes pneumoconiosis among farmworkers. / Schenker, Marc B.

In: Proceedings of the American Thoracic Society, Vol. 7, No. 2, 01.05.2010, p. 107-110.

Research output: Contribution to journalArticle

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