Inner ear protection and regeneration: A 'historical' perspective

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

PURPOSE OF REVIEW: In evaluating strategies to preserve or regenerate the cochlea, understanding the process of labyrinthine injury on a cellular and molecular level is crucial. Examination of inner ear injury reveals mechanism-specific types of damage, often at specific areas within the cochlea. Site-specific interventions can then be considered. RECENT FINDINGS: The review will briefly summarize the historical perspective of advancements in hearing science through 2006. Areas of research covered include hair cell protection, hair cell regeneration, spiral ganglion cell regeneration, and stria vascularis metabolic regulation. SUMMARY: The review will briefly summarize the early development of a few such site-specific interventions for inner ear functional rehabilitation, for work done prior to 2006. The outstanding reviews of cutting edge research from this year's and last year's Hearing Science section of Current Opinion in Otolaryngology - Head and Neck Surgery can then be understood and appreciated in a more informed manner.

Original languageEnglish (US)
Pages (from-to)363-372
Number of pages10
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Volume17
Issue number5
DOIs
StatePublished - Oct 2009

Keywords

  • Apoptosis
  • Direct transdifferentiation
  • Endocochlear potential
  • Gene therapy
  • Stem cells

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

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