Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

Ya Jen Chang, Hye Young Kim, Lee A. Albacker, Nicole Baumgarth, Andrew N J McKenzie, Dirk E. Smith, Rosemarie H. Dekruyff, Dale T. Umetsu

Research output: Contribution to journalArticle

529 Citations (Scopus)

Abstract

Patients with asthma, a major public health problem, are at high risk for serious disease from influenza virus infection, but the pathogenic mechanisms by which influenza A causes airway disease and asthma are not fully known. We show here in a mouse model that influenza infection acutely induced airway hyper-reactivity (AHR), a cardinal feature of asthma, independently of T helper type 2 (TH2) cells and adaptive immunity. Instead, influenza infection induced AHR through a previously unknown pathway that required the interleukin 13 (IL-13)-IL-33 axis and cells of the non-T cell, non-B cell innate lymphoid type called 'natural helper cells'. Infection with influenza A virus, which activates the NLRP3 inflammasome, resulted in much more production of IL-33 by alveolar macrophages, which in turn activated natural helper cells producing substantial IL-13.

Original languageEnglish (US)
Pages (from-to)631-638
Number of pages8
JournalNature Immunology
Volume12
Issue number7
DOIs
StatePublished - May 2011

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Adaptive Immunity
Human Influenza
Interleukin-13
Asthma
Lymphocytes
Helper-Inducer T-Lymphocytes
Infection
Inflammasomes
Th2 Cells
Influenza A virus
Alveolar Macrophages
Virus Diseases
Orthomyxoviridae
Public Health
Interleukin-33

ASJC Scopus subject areas

  • Immunology

Cite this

Chang, Y. J., Kim, H. Y., Albacker, L. A., Baumgarth, N., McKenzie, A. N. J., Smith, D. E., ... Umetsu, D. T. (2011). Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nature Immunology, 12(7), 631-638. https://doi.org/10.1038/ni.2045

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. / Chang, Ya Jen; Kim, Hye Young; Albacker, Lee A.; Baumgarth, Nicole; McKenzie, Andrew N J; Smith, Dirk E.; Dekruyff, Rosemarie H.; Umetsu, Dale T.

In: Nature Immunology, Vol. 12, No. 7, 05.2011, p. 631-638.

Research output: Contribution to journalArticle

Chang, YJ, Kim, HY, Albacker, LA, Baumgarth, N, McKenzie, ANJ, Smith, DE, Dekruyff, RH & Umetsu, DT 2011, 'Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity', Nature Immunology, vol. 12, no. 7, pp. 631-638. https://doi.org/10.1038/ni.2045
Chang, Ya Jen ; Kim, Hye Young ; Albacker, Lee A. ; Baumgarth, Nicole ; McKenzie, Andrew N J ; Smith, Dirk E. ; Dekruyff, Rosemarie H. ; Umetsu, Dale T. / Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. In: Nature Immunology. 2011 ; Vol. 12, No. 7. pp. 631-638.
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