Innate immunity and cardiomyocytes in ischemic heart disease

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Myocardial ischemia/reperfusion (I/R) is the most common cause of myocardial inflammation, which is primarily a manifestation of the innate immune responses. Innate immunity is activated when pattern recognition receptors (PRRs) respond to molecular patterns common to microbes and to danger signals expressed by injured or infected cells, so called pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). The expression of various PRRs in cardiomyocytes and the release of DAMPs from cardiomyocytes subjected to I/R injury, through active mechanisms as well as passive processes, enable cardiomyocytes to generate innate immune responses. Studies in isolated heart and cardiomyocytes have confirmed the inflammatory and functional effects of cardiac PRRs especially Toll-like receptors in response to I/R-derived DAMPs, such as heat shock proteins. This review addresses the active role of cardiomyocytes in mediating innate inflammatory responses to myocardial I/R. We propose that cardiomyocytes act as innate immune cells in myocardial I/R injury.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalLife Sciences
Volume100
Issue number1
DOIs
StatePublished - Mar 28 2014

Keywords

  • Cardiomyocytes
  • Heart
  • Inflammation
  • Innate immunity
  • Ischemia/reperfusion
  • NF-κB
  • Pattern recognition receptor
  • TLR2
  • TLR4

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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