Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system

Nicole Baumgarth, Ometa C. Herman, Gina C. Jager, Lorena Brown, Leonard A. Herzenberg, Leonore A. Herzenberg

Research output: Contribution to journalArticle

236 Citations (Scopus)

Abstract

'Natural' Igs, mainly IgM, comprise part of the innate immune system present in healthy individuals, including antigen-free mice. These Igs are thought to delay pathogenicity of infecting agents until antigen-induced high affinity Igs of all isotypes are produced. Previous studies suggested that the acquired humoral response arises directly from the innate response, i.e., that B cells expressing natural IgM, upon antigen encounter, differentiate to give rise both to cells that secrete high amounts of IgM and to cells that undergo affinity maturation and isotype switching. However, by using a murine model of influenza virus infection, we demonstrate here that the B cells that produce natural antiviral IgM neither increase their IgM production nor undergo isotype switching to IgG2a in response to the infection. These cells are distinct from the B cells that produce the antiviral response after encounter with the pathogen. Our data therefore demonstrate that the innate and the acquired humoral immunities to influenza virus are separate effector arms of the immune system and that antigen exposure per se is not sufficient to increase natural antibody production.

Original languageEnglish (US)
Pages (from-to)2250-2255
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number5
DOIs
StatePublished - Mar 2 1999
Externally publishedYes

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Adaptive Immunity
Humoral Immunity
Orthomyxoviridae
Immunoglobulin M
Immune System
Immunoglobulin Class Switching
Antigens
B-Lymphocytes
Antiviral Agents
Population Growth
Virus Diseases
Antibody Formation
Virulence
Infection

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system. / Baumgarth, Nicole; Herman, Ometa C.; Jager, Gina C.; Brown, Lorena; Herzenberg, Leonard A.; Herzenberg, Leonore A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 5, 02.03.1999, p. 2250-2255.

Research output: Contribution to journalArticle

Baumgarth, Nicole ; Herman, Ometa C. ; Jager, Gina C. ; Brown, Lorena ; Herzenberg, Leonard A. ; Herzenberg, Leonore A. / Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system. In: Proceedings of the National Academy of Sciences of the United States of America. 1999 ; Vol. 96, No. 5. pp. 2250-2255.
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