Initiation of fracture repair by bone morphogenetic proteins

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

The potential for regeneration and repair of bone is well known. This article conveys the current progress in the realm of bone morphogenetic proteins and their potential for initiating fracture repair cascade. Demineralized bone matrix induces bone formation and has served as a model for the bone repair cascade. A family of bone morphogenetic proteins has been identified, isolated, and cloned from the demineralized bone matrix. Bone morphogenetic proteins are pleiotropic regulators of chemotaxis, mitosis, and differentiation. The bone morphogenetic protein receptors, Types I and II, bind bone morphogenetic proteins and act in collaboration to transduce the phosphorylation of Smad 1 and Smad 5, which enter the nucleus in partnership with Smad 4 to initiate bone morphogenetic protein responses including fracture healing. The accumulated information on bone morphogenetic proteins may aid in accelerating fracture repair and the potential use of bone morphogenetic protein antibodies to inhibit heterotopic bone formation and fibrodysplasia ossificans progressiva.

Original languageEnglish (US)
JournalClinical Orthopaedics and Related Research
Issue number355 SUPPL.
StatePublished - 1998

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Bone Morphogenetic Proteins
Bone Matrix
Osteogenesis
Type I Bone Morphogenetic Protein Receptors
Type II Bone Morphogenetic Protein Receptors
Myositis Ossificans
Bone Regeneration
Fracture Healing
Chemotaxis
Mitosis
Phosphorylation
Bone and Bones
Antibodies

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Initiation of fracture repair by bone morphogenetic proteins. / Reddi, A Hari.

In: Clinical Orthopaedics and Related Research, No. 355 SUPPL., 1998.

Research output: Contribution to journalArticle

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