Initiation and promotion of endochondral bone formation by bone morphogenetic proteins: Potential implications for avian tibial dyschondroplasia

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The initiation and promotion of bone morphogenesis is regulated by bone morphogenetic proteins. Morphogenesis of the skeleton is the developmental cascade of pattern formation, establishment of mirror-image bilateral symmetry, initiation and promotion of endochondral bone differentiation, and growth culminating in functional weight bearing. Implantation of demineralized bone matrix initiates a developmental cascade of endochondral bone formation that is reminiscent of the sequential bone morphogenesis in the limb bud in the embryo. The inductive agents in the demineralized bone matrix were identified, isolated and cloned, and demonstrated to be bone morphogenetic proteins (BMP). The BMP have been implicated in the pattern formation, differentiation, and regeneration of bone. Because there is a persistent defect in endochondral bone formation in the epiphysed growth plate in tibial dyschondroplasia in poultry, it is likely that BMP signaling mechanisms may be impaired.

Original languageEnglish (US)
Pages (from-to)978-981
Number of pages4
JournalPoultry Science
Volume79
Issue number7
StatePublished - Jul 2000

Keywords

  • Avian tibial dyschondroplasia
  • Bone morphogenetic proteins
  • Endochondral bone formation

ASJC Scopus subject areas

  • Animal Science and Zoology

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