Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis

Athena Soulika, Eunyoung Lee, Erica McCauley, Laird Miers, Peter Bannerman, David E Pleasure

Research output: Contribution to journalArticle

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Abstract

Axonal loss is the principal cause of chronic disability in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). In C57BL/6 mice with EAE induced by immunization with myelin oligodendrocyte glycoprotein peptide 35-55, the first evidences of axonal damage in spinal cord were in acute subpial and perivascular foci of infiltrating neutrophils and lymphocytes and included intra-axonal accumulations of the endovesicular Toll-like receptor TLR8, and the inflammasome protein NAcht leucine-rich repeat protein 1 (NALP1). Later in the course of this illness, focal inflammatory infiltrates disappeared from the spinal cord, but there was persistent activation of spinal cord innate immunity and progressive, bilaterally symmetric loss of small-diameter corticospinal tract axons. These results support the hypothesis that both contact-dependent and paracrine interactions of systemic inflammatory cells with axons and an innate immune-mediated neurodegenerative process contribute to axonal loss in this multiple sclerosis model.

Original languageEnglish (US)
Pages (from-to)14965-14979
Number of pages15
JournalJournal of Neuroscience
Volume29
Issue number47
DOIs
StatePublished - Nov 25 2009

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Autoimmune Experimental Encephalomyelitis
Spinal Cord
Multiple Sclerosis
Axons
Inflammasomes
Pyramidal Tracts
Toll-Like Receptors
Inbred C57BL Mouse
Innate Immunity
Immunization
Neutrophils
Lymphocytes
Peptides
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

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Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. / Soulika, Athena; Lee, Eunyoung; McCauley, Erica; Miers, Laird; Bannerman, Peter; Pleasure, David E.

In: Journal of Neuroscience, Vol. 29, No. 47, 25.11.2009, p. 14965-14979.

Research output: Contribution to journalArticle

Soulika, Athena ; Lee, Eunyoung ; McCauley, Erica ; Miers, Laird ; Bannerman, Peter ; Pleasure, David E. / Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. In: Journal of Neuroscience. 2009 ; Vol. 29, No. 47. pp. 14965-14979.
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