Abstract
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 520-562 |
| Number of pages | 43 |
| Journal | Nature |
| Volume | 420 |
| Issue number | 6915 |
| DOIs | |
| State | Published - Dec 5 2002 |
| Externally published | Yes |
ASJC Scopus subject areas
- General
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Initial sequencing and comparative analysis of the mouse genome. / Waterston, Robert H.; Lindblad-Toh, Kerstin; Birney, Ewan; Rogers, Jane; Abril, Josep F.; Agarwal, Pankaj; Agarwala, Richa; Ainscough, Rachel; Alexandersson, Marina; An, Peter; Antonarakis, Stylianos E.; Attwood, John; Baertsch, Robert; Bailey, Jonathon; Barlow, Karen; Beck, Stephan; Berry, Eric; Birren, Bruce; Bloom, Toby; Bork, Peer; Botcherby, Marc; Bray, Nicolas; Brent, Michael R.; Brown, Daniel G.; Brown, Stephen D.; Bult, Carol; Burton, John; Butler, Jonathan; Campbell, Robert D.; Carninci, Piero; Cawley, Simon; Chiaromonte, Francesca; Chinwalla, Asif T.; Church, Deanna M.; Clamp, Michele; Clee, Christopher; Collins, Francis S.; Cook, Lisa L.; Copley, Richard R.; Coulson, Alan; Couronne, Olivier; Cuff, James; Curwen, Val; Cutts, Tim; Daly, Mark; David, Robert; Davies, Joy; Delehaunty, Kimberly D.; Deri, Justin; Dermitzakis, Emmanouil T.; Dewey, Colin; Dickens, Nicholas J.; Diekhans, Mark; Dodge, Sheila; Dubchak, Inna; Dunn, Diane M.; Eddy, Sean R.; Elnitski, Laura; Emes, Richard D.; Eswara, Pallavi; Eyras, Eduardo; Felsenfeld, Adam; Fewell, Ginger A.; Flicek, Paul; Foley, Karen; Frankel, Wayne N.; Fulton, Lucinda A.; Fulton, Robert S.; Furey, Terrence S.; Gage, Diane; Gibbs, Richard A.; Glusman, Gustavo; Gnerre, Sante; Goldman, Nick; Goodstadt, Leo; Grafham, Darren; Graves, Tina A.; Green, Eric D.; Gregory, Simon; Guigó, Roderic; Guyer, Mark; Hardison, Ross C.; Haussler, David; Hayashizaki, Yoshihide; LaHillier, Deana W.; Hinrichs, Angela; Hlavina, Wratko; Holzer, Timothy; Hsu, Fan; Hua, Axin; Hubbard, Tim; Hunt, Adrienne; Jackson, Ian; Jaffe, David B.; Johnson, L. Steven; Jones, Matthew; Jones, Thomas A.; Joy, Ann; Kamal, Michael; Karlsson, Elinor K.; Karolchik, Donna; Kasprzyk, Arkadiusz; Kawai, Jun; Keibler, Evan; Kells, Cristyn; Kent, W. James; Kirby, Andrew; Kolbe, Diana L.; Korf, Ian F; Kucherlapati, Raju S.; Kulbokas, Edward J.; Kulp, David; Landers, Tom; Leger, J. P.; Leonard, Steven; Letunic, Ivica; Levine, Rosie; Li, Jia; Li, Ming; Lloyd, Christine; Lucas, Susan; Ma, Bin; Maglott, Donna R.; Mardis, Elaine R.; Matthews, Lucy; Mauceli, Evan; Mayer, John H.; McCarthy, Megan; McCombie, W. Richard; McLaren, Stuart; McLay, Kirsten; Mcpherson, John Douglas; Meldrim, Jim; Meredith, Beverley; Mesirov, Jill P.; Miller, Webb; Miner, Tracie L.; Mongin, Emmanuel; Montgomery, Kate T.; Morgan, Michael; Mott, Richard; Mullikin, James C.; Muzny, Donna M.; Nash, William E.; Nelson, Joanne O.; Nhan, Michael N.; Nicol, Robert; Ning, Zemin; Nusbaum, Chad; O'Connor, Michael J.; Okazaki, Yasushi; Oliver, Karen; Overton-Larty, Emma; Pachter, Lior; Parra, Genís; Pepin, Kymberlie H.; Peterson, Jane; Pevzner, Pavel; Plumb, Robert; Pohl, Craig S.; Poliakov, Alex; Ponce, Tracy C.; Ponting, Chris P.; Potter, Simon; Quail, Michael; Reymond, Alexandre; Roe, Bruce A.; Roskin, Krishna M.; Rubin, Edward M.; Rust, Alistair G.; Santos, Ralph; Sapojnikov, Victor; Schultz, Brian; Schultz, Jorg; Schwartz, Matthias S.; Schwartz, Scott; Scott, Carol; Seaman, Steven; Searle, Steve; Sharpe, Ted; Sheridan, Andrew; Shownkeen, Ratna; Sims, Sarah; Singer, Jonathan B.; Slater, Guy; Smit, Arian; Smith, Douglas R.; Spencer, Brian; Stabenau, Arne; Stange-Thomann, Nicole; Sugnet, Charles; Suyama, Mikita; Tesler, Glenn; Thompson, Johanna; Torrents, David; Trevaskis, Evanne; Tromp, John; Ucla, Catherine; Ureta-Vidal, Abel; Vinson, Jade P.; von Niederhausern, Andrew C.; Wade, Claire M.; Wall, Melanie; Weber, Ryan J.; Weiss, Robert B.; Wendl, Michael C.; West, Anthony P.; Wetterstrand, Kris; Wheeler, Raymond; Whelan, Simon; Wierzbowski, Jamey; Willey, David; Williams, Sophie; Wilson, Richard K.; Winter, Eitan; Worley, Kim C.; Wyman, Dudley; Yang, Shan; Yang, Shiaw Pyng; Zdobnov, Evgeny M.; Zody, Michael C.; Lander, Eric S.
In: Nature, Vol. 420, No. 6915, 05.12.2002, p. 520-562.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Initial sequencing and comparative analysis of the mouse genome
AU - Waterston, Robert H.
AU - Lindblad-Toh, Kerstin
AU - Birney, Ewan
AU - Rogers, Jane
AU - Abril, Josep F.
AU - Agarwal, Pankaj
AU - Agarwala, Richa
AU - Ainscough, Rachel
AU - Alexandersson, Marina
AU - An, Peter
AU - Antonarakis, Stylianos E.
AU - Attwood, John
AU - Baertsch, Robert
AU - Bailey, Jonathon
AU - Barlow, Karen
AU - Beck, Stephan
AU - Berry, Eric
AU - Birren, Bruce
AU - Bloom, Toby
AU - Bork, Peer
AU - Botcherby, Marc
AU - Bray, Nicolas
AU - Brent, Michael R.
AU - Brown, Daniel G.
AU - Brown, Stephen D.
AU - Bult, Carol
AU - Burton, John
AU - Butler, Jonathan
AU - Campbell, Robert D.
AU - Carninci, Piero
AU - Cawley, Simon
AU - Chiaromonte, Francesca
AU - Chinwalla, Asif T.
AU - Church, Deanna M.
AU - Clamp, Michele
AU - Clee, Christopher
AU - Collins, Francis S.
AU - Cook, Lisa L.
AU - Copley, Richard R.
AU - Coulson, Alan
AU - Couronne, Olivier
AU - Cuff, James
AU - Curwen, Val
AU - Cutts, Tim
AU - Daly, Mark
AU - David, Robert
AU - Davies, Joy
AU - Delehaunty, Kimberly D.
AU - Deri, Justin
AU - Dermitzakis, Emmanouil T.
AU - Dewey, Colin
AU - Dickens, Nicholas J.
AU - Diekhans, Mark
AU - Dodge, Sheila
AU - Dubchak, Inna
AU - Dunn, Diane M.
AU - Eddy, Sean R.
AU - Elnitski, Laura
AU - Emes, Richard D.
AU - Eswara, Pallavi
AU - Eyras, Eduardo
AU - Felsenfeld, Adam
AU - Fewell, Ginger A.
AU - Flicek, Paul
AU - Foley, Karen
AU - Frankel, Wayne N.
AU - Fulton, Lucinda A.
AU - Fulton, Robert S.
AU - Furey, Terrence S.
AU - Gage, Diane
AU - Gibbs, Richard A.
AU - Glusman, Gustavo
AU - Gnerre, Sante
AU - Goldman, Nick
AU - Goodstadt, Leo
AU - Grafham, Darren
AU - Graves, Tina A.
AU - Green, Eric D.
AU - Gregory, Simon
AU - Guigó, Roderic
AU - Guyer, Mark
AU - Hardison, Ross C.
AU - Haussler, David
AU - Hayashizaki, Yoshihide
AU - LaHillier, Deana W.
AU - Hinrichs, Angela
AU - Hlavina, Wratko
AU - Holzer, Timothy
AU - Hsu, Fan
AU - Hua, Axin
AU - Hubbard, Tim
AU - Hunt, Adrienne
AU - Jackson, Ian
AU - Jaffe, David B.
AU - Johnson, L. Steven
AU - Jones, Matthew
AU - Jones, Thomas A.
AU - Joy, Ann
AU - Kamal, Michael
AU - Karlsson, Elinor K.
AU - Karolchik, Donna
AU - Kasprzyk, Arkadiusz
AU - Kawai, Jun
AU - Keibler, Evan
AU - Kells, Cristyn
AU - Kent, W. James
AU - Kirby, Andrew
AU - Kolbe, Diana L.
AU - Korf, Ian F
AU - Kucherlapati, Raju S.
AU - Kulbokas, Edward J.
AU - Kulp, David
AU - Landers, Tom
AU - Leger, J. P.
AU - Leonard, Steven
AU - Letunic, Ivica
AU - Levine, Rosie
AU - Li, Jia
AU - Li, Ming
AU - Lloyd, Christine
AU - Lucas, Susan
AU - Ma, Bin
AU - Maglott, Donna R.
AU - Mardis, Elaine R.
AU - Matthews, Lucy
AU - Mauceli, Evan
AU - Mayer, John H.
AU - McCarthy, Megan
AU - McCombie, W. Richard
AU - McLaren, Stuart
AU - McLay, Kirsten
AU - Mcpherson, John Douglas
AU - Meldrim, Jim
AU - Meredith, Beverley
AU - Mesirov, Jill P.
AU - Miller, Webb
AU - Miner, Tracie L.
AU - Mongin, Emmanuel
AU - Montgomery, Kate T.
AU - Morgan, Michael
AU - Mott, Richard
AU - Mullikin, James C.
AU - Muzny, Donna M.
AU - Nash, William E.
AU - Nelson, Joanne O.
AU - Nhan, Michael N.
AU - Nicol, Robert
AU - Ning, Zemin
AU - Nusbaum, Chad
AU - O'Connor, Michael J.
AU - Okazaki, Yasushi
AU - Oliver, Karen
AU - Overton-Larty, Emma
AU - Pachter, Lior
AU - Parra, Genís
AU - Pepin, Kymberlie H.
AU - Peterson, Jane
AU - Pevzner, Pavel
AU - Plumb, Robert
AU - Pohl, Craig S.
AU - Poliakov, Alex
AU - Ponce, Tracy C.
AU - Ponting, Chris P.
AU - Potter, Simon
AU - Quail, Michael
AU - Reymond, Alexandre
AU - Roe, Bruce A.
AU - Roskin, Krishna M.
AU - Rubin, Edward M.
AU - Rust, Alistair G.
AU - Santos, Ralph
AU - Sapojnikov, Victor
AU - Schultz, Brian
AU - Schultz, Jorg
AU - Schwartz, Matthias S.
AU - Schwartz, Scott
AU - Scott, Carol
AU - Seaman, Steven
AU - Searle, Steve
AU - Sharpe, Ted
AU - Sheridan, Andrew
AU - Shownkeen, Ratna
AU - Sims, Sarah
AU - Singer, Jonathan B.
AU - Slater, Guy
AU - Smit, Arian
AU - Smith, Douglas R.
AU - Spencer, Brian
AU - Stabenau, Arne
AU - Stange-Thomann, Nicole
AU - Sugnet, Charles
AU - Suyama, Mikita
AU - Tesler, Glenn
AU - Thompson, Johanna
AU - Torrents, David
AU - Trevaskis, Evanne
AU - Tromp, John
AU - Ucla, Catherine
AU - Ureta-Vidal, Abel
AU - Vinson, Jade P.
AU - von Niederhausern, Andrew C.
AU - Wade, Claire M.
AU - Wall, Melanie
AU - Weber, Ryan J.
AU - Weiss, Robert B.
AU - Wendl, Michael C.
AU - West, Anthony P.
AU - Wetterstrand, Kris
AU - Wheeler, Raymond
AU - Whelan, Simon
AU - Wierzbowski, Jamey
AU - Willey, David
AU - Williams, Sophie
AU - Wilson, Richard K.
AU - Winter, Eitan
AU - Worley, Kim C.
AU - Wyman, Dudley
AU - Yang, Shan
AU - Yang, Shiaw Pyng
AU - Zdobnov, Evgeny M.
AU - Zody, Michael C.
AU - Lander, Eric S.
PY - 2002/12/5
Y1 - 2002/12/5
N2 - The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
AB - The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
UR - http://www.scopus.com/inward/record.url?scp=1542563409&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542563409&partnerID=8YFLogxK
U2 - 10.1038/nature01262
DO - 10.1038/nature01262
M3 - Article
C2 - 12466850
AN - SCOPUS:1542563409
VL - 420
SP - 520
EP - 562
JO - Nature
JF - Nature
SN - 0028-0836
IS - 6915
ER -