Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: A multicenter survey

David Tanne, V. E. Bates, Piero Verro, S. E. Kasner, J. R. Binder, S. C. Patel, H. H. Mansbach, S. Daley, L. R. Schultz, P. N. Karanjia, P. Scott, J. M. Dayno, K. Vereczkey-Porter, C. Benesch, D. Book, W. M. Coplin, D. Dulli, S. R. Levine

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158 Scopus citations

Abstract

We assessed initial clinical experience with IV tissue plasminogen activator (t-PA) treatment of acute ischemic stroke in a standardized retrospective survey of hospitals with experienced acute stroke treatment systems. The incidence of symptomatic intracerebral hemorrhage (ICH) was 6% (11 of 189 patients; 95% CI 3 to 11%), similar to that in the National Institute of Neurological Disorders and Stroke (NINDS) t-PA Stroke Study. Deviations from the NINDS protocol guidelines were identified in 30% of patients (56 of 189). The incidence of symptomatic ICH was 11% among patients with protocol deviations as compared with 4% in patients who were treated according to the NINDS protocol guidelines, suggesting that strict adherence to protocol guidelines is prudent.

Original languageEnglish (US)
Pages (from-to)424-427
Number of pages4
JournalNeurology
Volume53
Issue number2
StatePublished - Jul 22 1999
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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