Initial clinical experience with helical tomotherapy for head and neck cancer

Allen M. Chen, Richard L S Jennelle, Radhika Sreeraman, Claus C. Yang, Tianxiao Liu, Srinivasan Vijayakumar, James A. Purdy

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background. To report a single-institutional experience with the use of helical tomotherapy (HT)-based intensity-modulated radiotherapy (IMRT) for head and neck cancer. Methods. Seventy-seven consecutive patients were treated with HT for squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60 to 72 Gy). Megavoltage CT scans were obtained as part of an image-guided registration protocol for patient alignment before each treatment. Concurrent chemotherapy was administered to 48 patients (62%). Results. The 2-year estimates of overall survival, localregional control, and disease-free survival were 82%, 77%, and 71%, respectively. Spatial evaluation of local-regional failures revealed that 16 of the 18 patients who progressed in the primary site or neck failed in the high-dose planning target volume (PTV). Conclusions. HT appears to achieve clinical outcomes comparable to contemporary series reporting on IMRT for head and neck cancer.

Original languageEnglish (US)
Pages (from-to)1571-1578
Number of pages8
JournalHead and Neck
Volume31
Issue number12
DOIs
StatePublished - Dec 2009

Keywords

  • Head and neck cancer
  • Helical tomotherapy
  • Intensity-modulated radiotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Chen, A. M., Jennelle, R. L. S., Sreeraman, R., Yang, C. C., Liu, T., Vijayakumar, S., & Purdy, J. A. (2009). Initial clinical experience with helical tomotherapy for head and neck cancer. Head and Neck, 31(12), 1571-1578. https://doi.org/10.1002/hed.21123