Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks

I. Fourel, O. Hantz, K. A. Watanabe, C. Jacquet, Bruno B Chomel, J. J. Fox, C. Trepo

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.

Original languageEnglish (US)
Pages (from-to)473-475
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number3
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)

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