The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.
|Original language||English (US)|
|Number of pages||3|
|Journal||Antimicrobial Agents and Chemotherapy|
|State||Published - 1990|
ASJC Scopus subject areas
- Pharmacology (medical)