Enterokinase, which is present in duodenal contents, converts trypsinogen to trypsin. Duodenopancreatic reflux of enterokinase may be responsible for many types of experimental and clinical pancreatitis. This hypothesis was confirmed when intraductal injection of enterokinase in rats produced hyperamylasemia and acute hemorrhagic pancreatitis. Concomitant intraductal administration of somatostatin (which reduces the volume and enzyme content of pancreatic secretion), cycloheximide or 5-azacytidine (inhibitors of protein synthesis) prevented hyperamylasemia and pancreatitis in this study.
|Original language||English (US)|
|Title of host publication||American Journal of Proctology Gastroenterology and Colon and Rectal Surgery|
|Number of pages||9|
|State||Published - 1981|
ASJC Scopus subject areas