Inhibitory effect of cycloheximide, somatostatin and 5-azacytidine on acute experimental pancreatitis

Nirmal S Mann, M. J. Mauch

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Enterokinase, which is present in duodenal contents, converts trypsinogen to trypsin. Duodenopancreatic reflux of enterokinase may be responsible for many types of experimental and clinical pancreatitis. This hypothesis was confirmed when intraductal injection of enterokinase in rats produced hyperamylasemia and acute hemorrhagic pancreatitis. Concomitant intraductal administration of somatostatin (which reduces the volume and enzyme content of pancreatic secretion), cycloheximide or 5-azacytidine (inhibitors of protein synthesis) prevented hyperamylasemia and pancreatitis in this study.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Proctology Gastroenterology and Colon and Rectal Surgery
Pages24-32
Number of pages9
Volume32
Edition7
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Mann, N. S., & Mauch, M. J. (1981). Inhibitory effect of cycloheximide, somatostatin and 5-azacytidine on acute experimental pancreatitis. In American Journal of Proctology Gastroenterology and Colon and Rectal Surgery (7 ed., Vol. 32, pp. 24-32)