Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury

Jerry S Powell, Jean Paul Clozel, Rita K M Müller, Herbert Kuhn, Fridolin Hefti, Markus Hosang, Hans R. Baumgartner

Research output: Contribution to journalArticle

999 Citations (Scopus)

Abstract

The role of a local angiotensin system in the vascular response to arterial injury was investigated by administering the angiotensin-converting enzyme (CE) inhibitor cilazapril to normotensive rats in which the left carotid artery was subjected to endothelial denudation and injury by balloon catheterization. In control animals, by 14 days after balloon injury, the processes of smooth muscle cell (SMC) proliferation, migration of SMCs from the media to the intima, and synthesis of extracellular matrix produced marked thickening of the intima, with reduction of the cross-sectional area of the lumen. However, in animals that received continuous treatment with the CE inhibitor, neointima formation was decreased (by about 80 percent), and lumen integrity was preserved. Thus, the angiotensin-converting enzyme may participate in modulating the proliferative response of the vascular wall after arterial injury, and inhibition of this enzyme may have therapeutic applications to prevent the proliferative lesions that occur after coronary angioplasty and vascular surgery.

Original languageEnglish (US)
Pages (from-to)186-188
Number of pages3
JournalScience
Volume245
Issue number4914
StatePublished - 1989
Externally publishedYes

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Vascular System Injuries
Angiotensin-Converting Enzyme Inhibitors
Blood Vessels
Wounds and Injuries
Cilazapril
Neointima
Angiotensins
Enzyme Inhibitors
Peptidyl-Dipeptidase A
Angioplasty
Carotid Arteries
Catheterization
Smooth Muscle Myocytes
Cell Movement
Extracellular Matrix
Cell Proliferation
Enzymes
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Powell, J. S., Clozel, J. P., Müller, R. K. M., Kuhn, H., Hefti, F., Hosang, M., & Baumgartner, H. R. (1989). Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science, 245(4914), 186-188.

Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. / Powell, Jerry S; Clozel, Jean Paul; Müller, Rita K M; Kuhn, Herbert; Hefti, Fridolin; Hosang, Markus; Baumgartner, Hans R.

In: Science, Vol. 245, No. 4914, 1989, p. 186-188.

Research output: Contribution to journalArticle

Powell, JS, Clozel, JP, Müller, RKM, Kuhn, H, Hefti, F, Hosang, M & Baumgartner, HR 1989, 'Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury', Science, vol. 245, no. 4914, pp. 186-188.
Powell JS, Clozel JP, Müller RKM, Kuhn H, Hefti F, Hosang M et al. Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science. 1989;245(4914):186-188.
Powell, Jerry S ; Clozel, Jean Paul ; Müller, Rita K M ; Kuhn, Herbert ; Hefti, Fridolin ; Hosang, Markus ; Baumgartner, Hans R. / Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. In: Science. 1989 ; Vol. 245, No. 4914. pp. 186-188.
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