Abstract
The role of a local angiotensin system in the vascular response to arterial injury was investigated by administering the angiotensin-converting enzyme (CE) inhibitor cilazapril to normotensive rats in which the left carotid artery was subjected to endothelial denudation and injury by balloon catheterization. In control animals, by 14 days after balloon injury, the processes of smooth muscle cell (SMC) proliferation, migration of SMCs from the media to the intima, and synthesis of extracellular matrix produced marked thickening of the intima, with reduction of the cross-sectional area of the lumen. However, in animals that received continuous treatment with the CE inhibitor, neointima formation was decreased (by about 80 percent), and lumen integrity was preserved. Thus, the angiotensin-converting enzyme may participate in modulating the proliferative response of the vascular wall after arterial injury, and inhibition of this enzyme may have therapeutic applications to prevent the proliferative lesions that occur after coronary angioplasty and vascular surgery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 186-188 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 245 |
| Issue number | 4914 |
| State | Published - 1989 |
| Externally published | Yes |
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Cite this
Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. / Powell, Jerry S; Clozel, Jean Paul; Müller, Rita K M; Kuhn, Herbert; Hefti, Fridolin; Hosang, Markus; Baumgartner, Hans R.
In: Science, Vol. 245, No. 4914, 1989, p. 186-188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury
AU - Powell, Jerry S
AU - Clozel, Jean Paul
AU - Müller, Rita K M
AU - Kuhn, Herbert
AU - Hefti, Fridolin
AU - Hosang, Markus
AU - Baumgartner, Hans R.
PY - 1989
Y1 - 1989
N2 - The role of a local angiotensin system in the vascular response to arterial injury was investigated by administering the angiotensin-converting enzyme (CE) inhibitor cilazapril to normotensive rats in which the left carotid artery was subjected to endothelial denudation and injury by balloon catheterization. In control animals, by 14 days after balloon injury, the processes of smooth muscle cell (SMC) proliferation, migration of SMCs from the media to the intima, and synthesis of extracellular matrix produced marked thickening of the intima, with reduction of the cross-sectional area of the lumen. However, in animals that received continuous treatment with the CE inhibitor, neointima formation was decreased (by about 80 percent), and lumen integrity was preserved. Thus, the angiotensin-converting enzyme may participate in modulating the proliferative response of the vascular wall after arterial injury, and inhibition of this enzyme may have therapeutic applications to prevent the proliferative lesions that occur after coronary angioplasty and vascular surgery.
AB - The role of a local angiotensin system in the vascular response to arterial injury was investigated by administering the angiotensin-converting enzyme (CE) inhibitor cilazapril to normotensive rats in which the left carotid artery was subjected to endothelial denudation and injury by balloon catheterization. In control animals, by 14 days after balloon injury, the processes of smooth muscle cell (SMC) proliferation, migration of SMCs from the media to the intima, and synthesis of extracellular matrix produced marked thickening of the intima, with reduction of the cross-sectional area of the lumen. However, in animals that received continuous treatment with the CE inhibitor, neointima formation was decreased (by about 80 percent), and lumen integrity was preserved. Thus, the angiotensin-converting enzyme may participate in modulating the proliferative response of the vascular wall after arterial injury, and inhibition of this enzyme may have therapeutic applications to prevent the proliferative lesions that occur after coronary angioplasty and vascular surgery.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024407452&partnerID=8YFLogxK
M3 - Article
VL - 245
SP - 186
EP - 188
JO - Science
JF - Science
SN - 0036-8075
IS - 4914
ER -