Inhibition of translation by cytotrienin A - A member of the ansamycin family

Lisa Lindqvist, Francis Robert, William Merrick, Hideaki Kakeya, Christopher Fraser, Hiroyuki Osada, Jerry Pelletier

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The ansamycins are a diverse and often physiologically active group of compounds that include geldanamycin and rifamycin, inhibitors of heat shock protein 90 and prokaryotic DNA-dependent RNA synthesis, respectively. Cytotrienin A is an ansamycintype small molecule with potent antiproliferative and proapoptotic properties. Here, we report that this compound inhibits eukaryotic protein synthesis by targeting translation elongation and interfering with eukaryotic elongation factor 1A function. We also find that cytotrienin A prevents HUVEC tube formation and diminishes microvessel formation in the chorioallantoic membrane assay. These results provide a molecular understanding into cytotrienin A's previously reported properties as an anticancer apoptosis-inducing drug. Published by Cold Spring Harbor Laboratory Press.

Original languageEnglish (US)
Pages (from-to)2404-2413
Number of pages10
Issue number12
StatePublished - Dec 2010


  • Cytotrienin A
  • eEF1A
  • Protein synthesis
  • Translation inhibitor

ASJC Scopus subject areas

  • Molecular Biology


Dive into the research topics of 'Inhibition of translation by cytotrienin A - A member of the ansamycin family'. Together they form a unique fingerprint.

Cite this