Inhibition of translation by cytotrienin A - A member of the ansamycin family

Lisa Lindqvist, Francis Robert, William Merrick, Hideaki Kakeya, Christopher Fraser, Hiroyuki Osada, Jerry Pelletier

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The ansamycins are a diverse and often physiologically active group of compounds that include geldanamycin and rifamycin, inhibitors of heat shock protein 90 and prokaryotic DNA-dependent RNA synthesis, respectively. Cytotrienin A is an ansamycintype small molecule with potent antiproliferative and proapoptotic properties. Here, we report that this compound inhibits eukaryotic protein synthesis by targeting translation elongation and interfering with eukaryotic elongation factor 1A function. We also find that cytotrienin A prevents HUVEC tube formation and diminishes microvessel formation in the chorioallantoic membrane assay. These results provide a molecular understanding into cytotrienin A's previously reported properties as an anticancer apoptosis-inducing drug. Published by Cold Spring Harbor Laboratory Press.

Original languageEnglish (US)
Pages (from-to)2404-2413
Number of pages10
JournalRNA
Volume16
Issue number12
DOIs
StatePublished - Dec 2010

Keywords

  • Cytotrienin A
  • eEF1A
  • Protein synthesis
  • Translation inhibitor

ASJC Scopus subject areas

  • Molecular Biology

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    Lindqvist, L., Robert, F., Merrick, W., Kakeya, H., Fraser, C., Osada, H., & Pelletier, J. (2010). Inhibition of translation by cytotrienin A - A member of the ansamycin family. RNA, 16(12), 2404-2413. https://doi.org/10.1261/rna.2307710