Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model

Jun Yan Liu, Hong Qiu, Christophe Morisseau, Sung Hee Hwang, Hsing Ju Tsai, Arzu Ulu, Nipavan Chiamvimonvat, Bruce D. Hammock

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The increasing use of the antimicrobial triclocarban (TCC) in personal care products (PCPs) has resulted in concern regarding environmental pollution. TCC is a potent inhibitor of soluble epoxide hydrolase (sEH). Inhibitors of sEH (sEHIs) are anti-inflammatory, anti-hypertensive and cardio-protective in multiple animal models. However, the in vivo effects anticipated from a sEHI have not been reported for TCC. Here we demonstrated the anti-inflammatory effects in vivo of TCC in a murine model. TCC was employed in a lipopolysaccharide (LPS)-challenged murine model. Systolic blood pressure, plasma levels of several inflammatory cytokines and chemokine, and metabolomic profile of plasma oxylipins were determined. TCC significantly reversed LPS-induced morbid hypotension in a time-dependent manner. TCC significantly repressed the increased release of inflammatory cytokines and chemokine caused by LPS. Furthermore, TCC significantly shifted the oxylipin profile in vivo in a time-dependent manner towards resolution of inflammation as expected from a sEHI. These results demonstrated that at the doses used TCC is anti-inflammatory in the murine model. This study suggests that TCC may provide some benefits in humans in addition to its antimicrobial activities due to its potent inhibition of sEH. It may be a promising starting point for developing new low volume high value applications of TCC. However these biological effects also caution against the general over use of TCC in PCPs.

Original languageEnglish (US)
Pages (from-to)200-206
Number of pages7
JournalToxicology and Applied Pharmacology
Volume255
Issue number2
DOIs
StatePublished - Sep 1 2011

Keywords

  • Hypotension
  • Lipopolysaccharide
  • Metabolic profiling
  • Metabolomics
  • Mice

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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