Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine

E. N. Frankel, J. B. German, J. E. Kinsella, E. Parks, J. Kanner

Research output: Contribution to journalArticle

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Abstract

The "French paradox" (apparent compatibility of a high fat diet with a low incidence of coronary atherosclerosis) has been attributed to the regular drinking of red wine. However, the alcohol content of wine may not be the sole explanation for this protection. Red wine also contains phenolic compounds, and the antioxidant properties of these may have an important role. In in-vitro studies with phenolic substances in red wine and normal human low-density lipoprotein (LDL) we found that red wine inhibits the coppercatalysed oxidation of LDL. Wine diluted 1000-fold containing 10 μmol/L total phenolics inhibited LDL oxidation significantly more than α-tocopherol. Our findings show that the non-alcoholic components of red wine have potent antioxidant properties toward oxidation of human LDL.

Original languageEnglish (US)
Pages (from-to)454-457
Number of pages4
JournalThe Lancet
Volume341
Issue number8843
DOIs
StatePublished - Feb 20 1993

ASJC Scopus subject areas

  • Medicine(all)

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    Frankel, E. N., German, J. B., Kinsella, J. E., Parks, E., & Kanner, J. (1993). Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. The Lancet, 341(8843), 454-457. https://doi.org/10.1016/0140-6736(93)90206-V