Abstract
We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%). The nonsteroidal antiinflammatory drug (NSAID), naproxen (NAP) had no effect on either enzyme activity over a therapeutic range (7-30 μg/ml) but at 120 μg/ml inhibited IL-1 induced caseinolytic and collagenolytic activity by 17 and 19%, respectively. However, PRED (2 μg/ml) in combination with NAP (30 μg/ml) significantly increased the inhibition of caseinolytic activity (p < 0.001) compared to that observed with PRED (2 μg/ml) alone. The suppression of IL-1 induced collagenolytic activity noted with PRED in combination with NAP did not exceed that observed with PRED alone.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 135-139 |
| Number of pages | 5 |
| Journal | Journal of Rheumatology |
| Volume | 19 |
| Issue number | 1 |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- chondrocyte
- interleukin 1
- metalloproteinase
- nonsteroidal antiinflammatory drugs
- prostaglandin E
- steroid
ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Inhibition of interleukin 1 induced chondrocyte protease activity by a corticosteroid and a nonsteroidal antiinflammatory drug. / Lane, Nancy E; Williams, R. J.; Schurman, D. J.; Smith, R. L.
In: Journal of Rheumatology, Vol. 19, No. 1, 1992, p. 135-139.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of interleukin 1 induced chondrocyte protease activity by a corticosteroid and a nonsteroidal antiinflammatory drug
AU - Lane, Nancy E
AU - Williams, R. J.
AU - Schurman, D. J.
AU - Smith, R. L.
PY - 1992
Y1 - 1992
N2 - We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%). The nonsteroidal antiinflammatory drug (NSAID), naproxen (NAP) had no effect on either enzyme activity over a therapeutic range (7-30 μg/ml) but at 120 μg/ml inhibited IL-1 induced caseinolytic and collagenolytic activity by 17 and 19%, respectively. However, PRED (2 μg/ml) in combination with NAP (30 μg/ml) significantly increased the inhibition of caseinolytic activity (p < 0.001) compared to that observed with PRED (2 μg/ml) alone. The suppression of IL-1 induced collagenolytic activity noted with PRED in combination with NAP did not exceed that observed with PRED alone.
AB - We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%). The nonsteroidal antiinflammatory drug (NSAID), naproxen (NAP) had no effect on either enzyme activity over a therapeutic range (7-30 μg/ml) but at 120 μg/ml inhibited IL-1 induced caseinolytic and collagenolytic activity by 17 and 19%, respectively. However, PRED (2 μg/ml) in combination with NAP (30 μg/ml) significantly increased the inhibition of caseinolytic activity (p < 0.001) compared to that observed with PRED (2 μg/ml) alone. The suppression of IL-1 induced collagenolytic activity noted with PRED in combination with NAP did not exceed that observed with PRED alone.
KW - chondrocyte
KW - interleukin 1
KW - metalloproteinase
KW - nonsteroidal antiinflammatory drugs
KW - prostaglandin E
KW - steroid
UR - http://www.scopus.com/inward/record.url?scp=0026596047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026596047&partnerID=8YFLogxK
M3 - Article
C2 - 1556675
AN - SCOPUS:0026596047
VL - 19
SP - 135
EP - 139
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 1
ER -