Abstract
We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%). The nonsteroidal antiinflammatory drug (NSAID), naproxen (NAP) had no effect on either enzyme activity over a therapeutic range (7-30 μg/ml) but at 120 μg/ml inhibited IL-1 induced caseinolytic and collagenolytic activity by 17 and 19%, respectively. However, PRED (2 μg/ml) in combination with NAP (30 μg/ml) significantly increased the inhibition of caseinolytic activity (p < 0.001) compared to that observed with PRED (2 μg/ml) alone. The suppression of IL-1 induced collagenolytic activity noted with PRED in combination with NAP did not exceed that observed with PRED alone.
Original language | English (US) |
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Pages (from-to) | 135-139 |
Number of pages | 5 |
Journal | Journal of Rheumatology |
Volume | 19 |
Issue number | 1 |
State | Published - 1992 |
Externally published | Yes |
Keywords
- chondrocyte
- interleukin 1
- metalloproteinase
- nonsteroidal antiinflammatory drugs
- prostaglandin E
- steroid
ASJC Scopus subject areas
- Immunology
- Rheumatology