Inhibition of interleukin 1 induced chondrocyte protease activity by a corticosteroid and a nonsteroidal antiinflammatory drug

Nancy E Lane; R. J. Williams; D. J. Schurman; R. L. Smith

Inhibition of interleukin 1 induced chondrocyte protease activity by a corticosteroid and a nonsteroidal antiinflammatory drug

Nancy E Lane, R. J. Williams, D. J. Schurman, R. L. Smith

Research output: Contribution to journal › Article › peer-review

Abstract

We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%). The nonsteroidal antiinflammatory drug (NSAID), naproxen (NAP) had no effect on either enzyme activity over a therapeutic range (7-30 μg/ml) but at 120 μg/ml inhibited IL-1 induced caseinolytic and collagenolytic activity by 17 and 19%, respectively. However, PRED (2 μg/ml) in combination with NAP (30 μg/ml) significantly increased the inhibition of caseinolytic activity (p < 0.001) compared to that observed with PRED (2 μg/ml) alone. The suppression of IL-1 induced collagenolytic activity noted with PRED in combination with NAP did not exceed that observed with PRED alone.

Original language	English (US)
Pages (from-to)	135-139
Number of pages	5
Journal	Journal of Rheumatology
Volume	19
Issue number	1
State	Published - 1992
Externally published	Yes

Keywords

chondrocyte
interleukin 1
metalloproteinase
nonsteroidal antiinflammatory drugs
prostaglandin E
steroid

ASJC Scopus subject areas

Immunology
Rheumatology

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title = "Inhibition of interleukin 1 induced chondrocyte protease activity by a corticosteroid and a nonsteroidal antiinflammatory drug",

abstract = "We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%). The nonsteroidal antiinflammatory drug (NSAID), naproxen (NAP) had no effect on either enzyme activity over a therapeutic range (7-30 μg/ml) but at 120 μg/ml inhibited IL-1 induced caseinolytic and collagenolytic activity by 17 and 19%, respectively. However, PRED (2 μg/ml) in combination with NAP (30 μg/ml) significantly increased the inhibition of caseinolytic activity (p < 0.001) compared to that observed with PRED (2 μg/ml) alone. The suppression of IL-1 induced collagenolytic activity noted with PRED in combination with NAP did not exceed that observed with PRED alone.",

keywords = "chondrocyte, interleukin 1, metalloproteinase, nonsteroidal antiinflammatory drugs, prostaglandin E, steroid",

author = "Lane, {Nancy E} and Williams, {R. J.} and Schurman, {D. J.} and Smith, {R. L.}",

year = "1992",

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T1 - Inhibition of interleukin 1 induced chondrocyte protease activity by a corticosteroid and a nonsteroidal antiinflammatory drug

AU - Lane, Nancy E

AU - Williams, R. J.

AU - Schurman, D. J.

AU - Smith, R. L.

PY - 1992

Y1 - 1992

N2 - We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%). The nonsteroidal antiinflammatory drug (NSAID), naproxen (NAP) had no effect on either enzyme activity over a therapeutic range (7-30 μg/ml) but at 120 μg/ml inhibited IL-1 induced caseinolytic and collagenolytic activity by 17 and 19%, respectively. However, PRED (2 μg/ml) in combination with NAP (30 μg/ml) significantly increased the inhibition of caseinolytic activity (p < 0.001) compared to that observed with PRED (2 μg/ml) alone. The suppression of IL-1 induced collagenolytic activity noted with PRED in combination with NAP did not exceed that observed with PRED alone.

AB - We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%). The nonsteroidal antiinflammatory drug (NSAID), naproxen (NAP) had no effect on either enzyme activity over a therapeutic range (7-30 μg/ml) but at 120 μg/ml inhibited IL-1 induced caseinolytic and collagenolytic activity by 17 and 19%, respectively. However, PRED (2 μg/ml) in combination with NAP (30 μg/ml) significantly increased the inhibition of caseinolytic activity (p < 0.001) compared to that observed with PRED (2 μg/ml) alone. The suppression of IL-1 induced collagenolytic activity noted with PRED in combination with NAP did not exceed that observed with PRED alone.

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KW - interleukin 1

KW - metalloproteinase

KW - nonsteroidal antiinflammatory drugs

KW - prostaglandin E

KW - steroid

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