Abstract
Carbohydrates are a component of chyme that initiate feedback control of gastric emptying. The aim of the study was to investigate the mechanism by which sensors in the intestine are activated by carbohydrate to initiate intestinal feedback of gastric motor Junction. Intestinal perfusion with D-glucose inhibited gastric motility in awake rats. This response was reproduced by 3-O-methyl glucose, a non-metabolizable analogue of glucose that is a bsorbed by the Na+-glucose cotransporter, but not by 2-deoxy-D-glucose, and was attenuated by perfusion of the intestine with phloridzin, a competitive blocker of the Na+-glucose cotransporter. Feeding a high carbohydrate diet to increase the number of co-transporters reduced the response to intestinal glucose. It was concluded that activation of sensors to initiate feedback inhibition of gastric motility may be dependent either on rapid accumulation of glucose within epithelial cells or on activation of the Na+-glucose co-transporter.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9-14 |
| Number of pages | 6 |
| Journal | Neurogastroenterology Motility |
| Volume | 7 |
| Issue number | 1 |
| State | Published - 1995 |
| Externally published | Yes |
Keywords
- Absorption
- Feedback inhibition
- Gastric motility
- Glucose
- Intestine
ASJC Scopus subject areas
- Physiology
- Gastroenterology
- Neuroscience(all)