Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules

Tonja J Roberts Webb, Roberta A. Litavecz, Masood A. Khan, Wenjun Du, Jacquelyn Gervay-Hague, Gourapura J. Renukaradhya, Randy R. Brutkiewicz

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.

Original languageEnglish (US)
Pages (from-to)2595-2600
Number of pages6
JournalEuropean Journal of Immunology
Volume36
Issue number10
DOIs
StatePublished - Oct 2006

Keywords

  • Antigen presentation
  • CD1d
  • Immune evasion
  • NKT cells
  • Vaccinia virus

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules'. Together they form a unique fingerprint.

  • Cite this

    Webb, T. J. R., Litavecz, R. A., Khan, M. A., Du, W., Gervay-Hague, J., Renukaradhya, G. J., & Brutkiewicz, R. R. (2006). Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules. European Journal of Immunology, 36(10), 2595-2600. https://doi.org/10.1002/eji.200636024