Abstract
A major effort in Alzheimers disease therapeutic development has targeted Aβ and downstream events. We have synthesized a small library of tricyclic pyrone compounds. Their protective action in MC65 cells and inhibition of ACAT along with the upregulation of cholesterol transporter gene were investigated. Five active compounds exhibited potencies in the nanomolar ranges. The multiple effects of the compounds on Aβ and cellular cholesterol pathways could be potential mechanisms underlying the protective effects in vivo.
Original language | English (US) |
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Pages (from-to) | 8969-8973 |
Number of pages | 5 |
Journal | Journal of Medicinal Chemistry |
Volume | 55 |
Issue number | 20 |
DOIs | |
State | Published - Oct 25 2012 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery