Inherited and acquired vulnerability to ventricular arrhythmias: Cardiac Na+ and K+ channels

Colleen E Clancy, Robert S. Kass

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Mutations in cardiac Na+ and K+ channels can disrupt the precise balance of ionic currents that underlies normal cardiac excitation and relaxation. Disruption of this equilibrium can result in arrhythmogenic phenotypes leading to syncope, seizures, and sudden cardiac death. Congenital defects result in an unpredictable expression of phenotypes with variable penetrance, even within single families. Additionally, phenotypically opposite and overlapping cardiac arrhythmogenic syndromes can stem from one mutation. A number of these defects have been characterized experimentally with the aim of understanding mechanisms of mutation-induced arrhythmia. Improving understanding of abnormalities may provide a basis for the development of therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)33-47
Number of pages15
JournalPhysiological Reviews
Volume85
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

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Cardiac Arrhythmias
Mutation
Phenotype
Penetrance
Sudden Cardiac Death
Syncope
Seizures
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

Inherited and acquired vulnerability to ventricular arrhythmias : Cardiac Na+ and K+ channels. / Clancy, Colleen E; Kass, Robert S.

In: Physiological Reviews, Vol. 85, No. 1, 01.2005, p. 33-47.

Research output: Contribution to journalArticle

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