Inherited 7 S immunoglobulin deficiency in chickens: Late onset dysgammaglobulinemia and evaluation of the lymphocyte proliferative responses and other immunologic functions

A. A. Benedict, L. Q. Tam, T. C. Chanh, L. W. Pollard, H. Abplanalp, M. Eric Gershwin

Research output: Contribution to journalArticle

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Abstract

The age-dependent responses of immunoglobulin (Ig) production and its correlation with normal immune function was studied in University of California, Davis (UCD), line 140 chickens, an animal model which develops a syndrome analogous to acquired agammaglobulinemia of humans. For approximately 50 days after hatching, UCD 140 birds generally have normal serum Ig levels. This is then followed by the appearance of dysgammaglobulinemia. The dysgammaglobulinemia was characterized as selective 7 S Ig deficiency, with increased serum levels of IgM, and either normal or moderately elevated levels of IgA. In contrast, the proliferative responses of peripheral blood lymphocytes (PBL) to T- and B-cell mitogens, the in vivo and in vitro delayed hypersensitivity responses to tuberculin, and the serum hemolytic complement levels of UCD 140 birds appeared normal and there was no significant reduction in Ig-bearing PBL. Dysgammaglobulinemic birds with no detectable 7 S Ig were capable of mounting vigorous IgM primary antibody responses to sheep red blood cells and to dinitrophenyl and secondary IgM responses to dinitrophenyl. Finally, the disease was not clearly associated with the major histocompatibility complex genotypes.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalClinical Immunology and Immunopathology
Volume17
Issue number1
DOIs
StatePublished - 1980

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Dysgammaglobulinemia
Immunoglobulins
Chickens
Lymphocytes
Birds
Immunoglobulin M
Serum
Agammaglobulinemia
Tuberculin
Delayed Hypersensitivity
Major Histocompatibility Complex
Mitogens
Immunoglobulin A
Antibody Formation
Sheep
Complement System Proteins
B-Lymphocytes
Animal Models
Erythrocytes
Genotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pathology and Forensic Medicine

Cite this

Inherited 7 S immunoglobulin deficiency in chickens : Late onset dysgammaglobulinemia and evaluation of the lymphocyte proliferative responses and other immunologic functions. / Benedict, A. A.; Tam, L. Q.; Chanh, T. C.; Pollard, L. W.; Abplanalp, H.; Gershwin, M. Eric.

In: Clinical Immunology and Immunopathology, Vol. 17, No. 1, 1980, p. 1-14.

Research output: Contribution to journalArticle

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