The age-dependent responses of immunoglobulin (Ig) production and its correlation with normal immune function was studied in University of California, Davis (UCD), line 140 chickens, an animal model which develops a syndrome analogous to acquired agammaglobulinemia of humans. For approximately 50 days after hatching, UCD 140 birds generally have normal serum Ig levels. This is then followed by the appearance of dysgammaglobulinemia. The dysgammaglobulinemia was characterized as selective 7 S Ig deficiency, with increased serum levels of IgM, and either normal or moderately elevated levels of IgA. In contrast, the proliferative responses of peripheral blood lymphocytes (PBL) to T- and B-cell mitogens, the in vivo and in vitro delayed hypersensitivity responses to tuberculin, and the serum hemolytic complement levels of UCD 140 birds appeared normal and there was no significant reduction in Ig-bearing PBL. Dysgammaglobulinemic birds with no detectable 7 S Ig were capable of mounting vigorous IgM primary antibody responses to sheep red blood cells and to dinitrophenyl and secondary IgM responses to dinitrophenyl. Finally, the disease was not clearly associated with the major histocompatibility complex genotypes.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine