Inheritance of cerebellar abiotrophy in Arabians

Leah S. Brault, Thomas R. Famula, Cecilia Penedo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective-To determine the mode of inheritance for cerebellar abiotrophy (CA), a neurologic disease in Arabians. Animals-804 Arabians, including 29 horses (15 males and 14 females) with CA. Procedures-Most horses (n = 755) belonged to 1 of 4 paternal families. Among the 29 CA-affected horses, all had clinical signs consistent with the disease; the disease was confirmed histologically following euthanasia in 8 horses. From the pedigree information, inbreeding coefficients were calculated for 16 affected horses and compared with coefficients for a subgroup of 16 unaffected horses. Complex segregation analysis was used to determine the effect of a putative Mendelian locus on the development of the disease and the probable mode of inheritance of CA. Results-The mean inbreeding coefficient was 0.0871 for CA-affected and unaffected horses, suggesting that all of the Arabians were inbred to the same degree and that affected horses were not more inbred than were unaffected horses. Results of the complex segregation analysis were consistent with a single Mendelian autosomal recessive mode of inheritance. Conclusions and Clinical Relevance-Knowledge of the mode of inheritance of CA should help breeders to make informed decisions regarding the selection of animals for mating when closely related horses have developed CA or produced CA-affected foals.

Original languageEnglish (US)
Pages (from-to)940-944
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume72
Issue number7
DOIs
StatePublished - Jul 1 2011

Fingerprint

Arabian (horse breed)
Horses
inheritance (genetics)
horses
Inbreeding
inbreeding coefficient
Euthanasia
nervous system diseases
euthanasia
Pedigree
Nervous System Diseases
foals
pedigree
animals

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Inheritance of cerebellar abiotrophy in Arabians. / Brault, Leah S.; Famula, Thomas R.; Penedo, Cecilia.

In: American Journal of Veterinary Research, Vol. 72, No. 7, 01.07.2011, p. 940-944.

Research output: Contribution to journalArticle

Brault, Leah S. ; Famula, Thomas R. ; Penedo, Cecilia. / Inheritance of cerebellar abiotrophy in Arabians. In: American Journal of Veterinary Research. 2011 ; Vol. 72, No. 7. pp. 940-944.
@article{888c87f3c3314a998bd709d553e7ced5,
title = "Inheritance of cerebellar abiotrophy in Arabians",
abstract = "Objective-To determine the mode of inheritance for cerebellar abiotrophy (CA), a neurologic disease in Arabians. Animals-804 Arabians, including 29 horses (15 males and 14 females) with CA. Procedures-Most horses (n = 755) belonged to 1 of 4 paternal families. Among the 29 CA-affected horses, all had clinical signs consistent with the disease; the disease was confirmed histologically following euthanasia in 8 horses. From the pedigree information, inbreeding coefficients were calculated for 16 affected horses and compared with coefficients for a subgroup of 16 unaffected horses. Complex segregation analysis was used to determine the effect of a putative Mendelian locus on the development of the disease and the probable mode of inheritance of CA. Results-The mean inbreeding coefficient was 0.0871 for CA-affected and unaffected horses, suggesting that all of the Arabians were inbred to the same degree and that affected horses were not more inbred than were unaffected horses. Results of the complex segregation analysis were consistent with a single Mendelian autosomal recessive mode of inheritance. Conclusions and Clinical Relevance-Knowledge of the mode of inheritance of CA should help breeders to make informed decisions regarding the selection of animals for mating when closely related horses have developed CA or produced CA-affected foals.",
author = "Brault, {Leah S.} and Famula, {Thomas R.} and Cecilia Penedo",
year = "2011",
month = "7",
day = "1",
doi = "10.2460/ajvr.72.7.940",
language = "English (US)",
volume = "72",
pages = "940--944",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "7",

}

TY - JOUR

T1 - Inheritance of cerebellar abiotrophy in Arabians

AU - Brault, Leah S.

AU - Famula, Thomas R.

AU - Penedo, Cecilia

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Objective-To determine the mode of inheritance for cerebellar abiotrophy (CA), a neurologic disease in Arabians. Animals-804 Arabians, including 29 horses (15 males and 14 females) with CA. Procedures-Most horses (n = 755) belonged to 1 of 4 paternal families. Among the 29 CA-affected horses, all had clinical signs consistent with the disease; the disease was confirmed histologically following euthanasia in 8 horses. From the pedigree information, inbreeding coefficients were calculated for 16 affected horses and compared with coefficients for a subgroup of 16 unaffected horses. Complex segregation analysis was used to determine the effect of a putative Mendelian locus on the development of the disease and the probable mode of inheritance of CA. Results-The mean inbreeding coefficient was 0.0871 for CA-affected and unaffected horses, suggesting that all of the Arabians were inbred to the same degree and that affected horses were not more inbred than were unaffected horses. Results of the complex segregation analysis were consistent with a single Mendelian autosomal recessive mode of inheritance. Conclusions and Clinical Relevance-Knowledge of the mode of inheritance of CA should help breeders to make informed decisions regarding the selection of animals for mating when closely related horses have developed CA or produced CA-affected foals.

AB - Objective-To determine the mode of inheritance for cerebellar abiotrophy (CA), a neurologic disease in Arabians. Animals-804 Arabians, including 29 horses (15 males and 14 females) with CA. Procedures-Most horses (n = 755) belonged to 1 of 4 paternal families. Among the 29 CA-affected horses, all had clinical signs consistent with the disease; the disease was confirmed histologically following euthanasia in 8 horses. From the pedigree information, inbreeding coefficients were calculated for 16 affected horses and compared with coefficients for a subgroup of 16 unaffected horses. Complex segregation analysis was used to determine the effect of a putative Mendelian locus on the development of the disease and the probable mode of inheritance of CA. Results-The mean inbreeding coefficient was 0.0871 for CA-affected and unaffected horses, suggesting that all of the Arabians were inbred to the same degree and that affected horses were not more inbred than were unaffected horses. Results of the complex segregation analysis were consistent with a single Mendelian autosomal recessive mode of inheritance. Conclusions and Clinical Relevance-Knowledge of the mode of inheritance of CA should help breeders to make informed decisions regarding the selection of animals for mating when closely related horses have developed CA or produced CA-affected foals.

UR - http://www.scopus.com/inward/record.url?scp=79960156617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960156617&partnerID=8YFLogxK

U2 - 10.2460/ajvr.72.7.940

DO - 10.2460/ajvr.72.7.940

M3 - Article

C2 - 21728855

AN - SCOPUS:79960156617

VL - 72

SP - 940

EP - 944

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 7

ER -