Inheritance of cataracts and primary lens luxation in Jack Russell Terriers

Anita M. Oberbauer, Steven R Hollingsworth, Janelle M. Belanger, Kelly R. Regan, Thomas R. Famula

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective - To characterize heritability and mode of inheritance of cataracts and primary lens luxation in Jack Russell Terriers. Animals - 872 Jack Russell Terriers from which buccal epithelial cells were collected and phenotypes for cataracts and lens luxation were determined and an additional 1,898 Jack Russell Terriers without phenotypic information used to complete pedigree relationships and that were included in the analyses. Procedures - Narrow-sense heritabilities and genetic correlation for cataracts and lens luxation were modeled by use of threshold analysis, whereas complex segregation analysis was used to characterize mode of inheritance. For the analyses, dogs < 6 years old, unless confirmed as having cataracts or lens luxation, were classified as an unknown phenotype. The possible involvement of an HSF4 mutation in cataracts was determined by DNA sequencing. Results - Cataracts and primary lens luxation were highly heritable and genetically correlated, and neither was controlled by a single gene. Cataracts were not associated with an HSF4 mutation. Conclusions and Clinical Relevance - Analysis of the data indicated that concerted selection against both cataracts and primary lens luxation when choosing breeding animals can be used to improve ocular health in Jack Russell Terriers.

Original languageEnglish (US)
Pages (from-to)222-227
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume69
Issue number2
DOIs
StatePublished - Feb 2008

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terriers
cataract
Lens
Cataract
Lenses
inheritance (genetics)
heritability
Phenotype
mutation
phenotype
Mutation
Cheek
animal breeding
Pedigree
DNA Sequence Analysis
pedigree
genetic correlation
Breeding
data analysis
epithelial cells

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Inheritance of cataracts and primary lens luxation in Jack Russell Terriers. / Oberbauer, Anita M.; Hollingsworth, Steven R; Belanger, Janelle M.; Regan, Kelly R.; Famula, Thomas R.

In: American Journal of Veterinary Research, Vol. 69, No. 2, 02.2008, p. 222-227.

Research output: Contribution to journalArticle

Oberbauer, Anita M. ; Hollingsworth, Steven R ; Belanger, Janelle M. ; Regan, Kelly R. ; Famula, Thomas R. / Inheritance of cataracts and primary lens luxation in Jack Russell Terriers. In: American Journal of Veterinary Research. 2008 ; Vol. 69, No. 2. pp. 222-227.
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