Inhaled nitric oxide use in preterm infants in California neonatal intensive care units

S. C. Handley, Robin H Steinhorn, A. O. Hopper, B. Govindaswami, D. R. Bhatt, K. P. Van Meurs, R. L. Ariagno, J. B. Gould, H. C. Lee

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objective:To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in neonatal intensive care unit (NICU) use.Study Design:This was a retrospective cohort study of infants, 22 to 33+6/7 weeks of gestational age (GA), during 2005 to 2013. Analyses were stratified by GA and included population characteristics, iNO use over time and hospital variation.Results:Of the 65 824 infants, 1718 (2.61%) received iNO. Infants, 22 to 24+6/7 weeks of GA, had the highest incidence of iNO exposure (6.54%). Community NICUs (n=77, median hospital use rate 0.7%) used less iNO than regional NICUs (n=23, median hospital use rate 5.8%). In 22 to 24+6/7 weeks of GA infants, the median rate in regional centers was 10.6% (hospital interquartile range 3.8% to 22.6%).Conclusion:iNO exposure varied with GA and hospital level, with the most use in extremely premature infants and regional centers. Variation reflects a lack of consensus regarding the appropriate use of iNO for preterm infants.

Original languageEnglish (US)
Pages (from-to)635-639
Number of pages5
JournalJournal of Perinatology
Volume36
Issue number8
DOIs
StatePublished - Aug 1 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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    Handley, S. C., Steinhorn, R. H., Hopper, A. O., Govindaswami, B., Bhatt, D. R., Van Meurs, K. P., Ariagno, R. L., Gould, J. B., & Lee, H. C. (2016). Inhaled nitric oxide use in preterm infants in California neonatal intensive care units. Journal of Perinatology, 36(8), 635-639. https://doi.org/10.1038/jp.2016.49