Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects

Marieann Högman; Dóra Lúdvíksdóttir; Sandra D. Anderson; Steven George; Lena Håkansson; H. K. Chan; Pekka Meriläinen; Hans Hedenström

doi:10.1016/S0034-5687(00)00195-X

Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects

Marieann Högman, Dóra Lúdvíksdóttir, Sandra D. Anderson, Steven George, Lena Håkansson, H. K. Chan, Pekka Meriläinen, Hans Hedenström

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We investigated if healthy subjects could release NO upon hyperosmolar challenge as a defence mechanism, and whether asthmatics with atopy showed an altered response. A plot of NO output versus flow rate was used to calculate the alveolar level and the NO-flux from the airways. The asthmatics had a higher NO output and this was due to an increased NO-flux from the airways, 86±30 nl min^-1 compared with control 21±2 nl min^-1 (P<0.05). The alveolar NO levels showed no difference. In response to a dry powder of mannitol the exhaled NO concentration decreased in asthmatics by 37±7%, but increased in the control by 9±4% (P<0.001). The FEV_1.0 decreased 13±2% and airway conductance 42±7% in asthmatics and in the controls 2±1% and 0±7%, respectively (P<0.001). We conclude that asthmatics have an altered response to mannitol challenge in regards to exhaled NO. This may result from down regulation of constitutive NO production as a result of high levels of NO flux from the airways.

Original language	English (US)
Pages (from-to)	141-150
Number of pages	10
Journal	Respiration Physiology
Volume	124
Issue number	2
DOIs	https://doi.org/10.1016/S0034-5687(00)00195-X
State	Published - Jan 20 2001

Keywords

Disease, asthma
Mammals, humans
Mediator, NO
Pharmacological agents, mannitol
Upper airways, inflammation

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

Access to Document

10.1016/S0034-5687(00)00195-X

Fingerprint Dive into the research topics of 'Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects'. Together they form a unique fingerprint.

Cite this

Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects. / Högman, Marieann; Lúdvíksdóttir, Dóra; Anderson, Sandra D.; George, Steven; Håkansson, Lena; Chan, H. K.; Meriläinen, Pekka; Hedenström, Hans.

In: Respiration Physiology, Vol. 124, No. 2, 20.01.2001, p. 141-150.

Research output: Contribution to journal › Article › peer-review

@article{fb25f7c6c35e4bc8af193921eab588f4,

title = "Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects",

abstract = "We investigated if healthy subjects could release NO upon hyperosmolar challenge as a defence mechanism, and whether asthmatics with atopy showed an altered response. A plot of NO output versus flow rate was used to calculate the alveolar level and the NO-flux from the airways. The asthmatics had a higher NO output and this was due to an increased NO-flux from the airways, 86±30 nl min-1 compared with control 21±2 nl min-1 (P<0.05). The alveolar NO levels showed no difference. In response to a dry powder of mannitol the exhaled NO concentration decreased in asthmatics by 37±7%, but increased in the control by 9±4% (P<0.001). The FEV1.0 decreased 13±2% and airway conductance 42±7% in asthmatics and in the controls 2±1% and 0±7%, respectively (P<0.001). We conclude that asthmatics have an altered response to mannitol challenge in regards to exhaled NO. This may result from down regulation of constitutive NO production as a result of high levels of NO flux from the airways.",

keywords = "Disease, asthma, Mammals, humans, Mediator, NO, Pharmacological agents, mannitol, Upper airways, inflammation",

author = "Marieann H{\"o}gman and D{\'o}ra L{\'u}dv{\'i}ksd{\'o}ttir and Anderson, {Sandra D.} and Steven George and Lena H{\aa}kansson and Chan, {H. K.} and Pekka Meril{\"a}inen and Hans Hedenstr{\"o}m",

year = "2001",

month = jan,

day = "20",

doi = "10.1016/S0034-5687(00)00195-X",

language = "English (US)",

volume = "124",

pages = "141--150",

journal = "Respiratory Physiology and Neurobiology",

issn = "1569-9048",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects

AU - Högman, Marieann

AU - Lúdvíksdóttir, Dóra

AU - Anderson, Sandra D.

AU - George, Steven

AU - Håkansson, Lena

AU - Chan, H. K.

AU - Meriläinen, Pekka

AU - Hedenström, Hans

PY - 2001/1/20

Y1 - 2001/1/20

N2 - We investigated if healthy subjects could release NO upon hyperosmolar challenge as a defence mechanism, and whether asthmatics with atopy showed an altered response. A plot of NO output versus flow rate was used to calculate the alveolar level and the NO-flux from the airways. The asthmatics had a higher NO output and this was due to an increased NO-flux from the airways, 86±30 nl min-1 compared with control 21±2 nl min-1 (P<0.05). The alveolar NO levels showed no difference. In response to a dry powder of mannitol the exhaled NO concentration decreased in asthmatics by 37±7%, but increased in the control by 9±4% (P<0.001). The FEV1.0 decreased 13±2% and airway conductance 42±7% in asthmatics and in the controls 2±1% and 0±7%, respectively (P<0.001). We conclude that asthmatics have an altered response to mannitol challenge in regards to exhaled NO. This may result from down regulation of constitutive NO production as a result of high levels of NO flux from the airways.

AB - We investigated if healthy subjects could release NO upon hyperosmolar challenge as a defence mechanism, and whether asthmatics with atopy showed an altered response. A plot of NO output versus flow rate was used to calculate the alveolar level and the NO-flux from the airways. The asthmatics had a higher NO output and this was due to an increased NO-flux from the airways, 86±30 nl min-1 compared with control 21±2 nl min-1 (P<0.05). The alveolar NO levels showed no difference. In response to a dry powder of mannitol the exhaled NO concentration decreased in asthmatics by 37±7%, but increased in the control by 9±4% (P<0.001). The FEV1.0 decreased 13±2% and airway conductance 42±7% in asthmatics and in the controls 2±1% and 0±7%, respectively (P<0.001). We conclude that asthmatics have an altered response to mannitol challenge in regards to exhaled NO. This may result from down regulation of constitutive NO production as a result of high levels of NO flux from the airways.

KW - Disease, asthma

KW - Mammals, humans

KW - Mediator, NO

KW - Pharmacological agents, mannitol

KW - Upper airways, inflammation

UR - http://www.scopus.com/inward/record.url?scp=0035170367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035170367&partnerID=8YFLogxK

U2 - 10.1016/S0034-5687(00)00195-X

DO - 10.1016/S0034-5687(00)00195-X

M3 - Article

C2 - 11164205

AN - SCOPUS:0035170367

VL - 124

SP - 141

EP - 150

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 2

ER -

Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this