Abstract
Cardiogenic global brain hypoxia-ischemia is a devastating medical problem that is associated with unfavorable neurologic outcomes. Low dose hydrogen gas (up to 2.9%) has been shown to be neuroprotective in a variety of brain diseases. In the present study, we investigated the protective effect of water by electrolysis-derived high concentration hydrogen gas (60%) in a rat model of asphyxia induced-cardiac arrest and global brain hypoxia-ischemia. High concentration hydrogen gas was either administered starting 1 hour prior to cardiac arrest for 1 hour and starting 1 hour post-resuscitation for 1 hour (pre- & post-treatment) or starting 1 hour post-resuscitation for 2 hours (post-treatment). In animals subjected to 9 minutes of asphyxia, both therapeutic regimens tended to reduce the incidence of seizures and neurological deficits within 3 days post-resuscitation. In rats subjected to 11 minutes of asphyxia, significantly worse neurological deficits were observed compared to 9 minutes asphyxia, and pre- & post-treatment had a tendency to improve the success rate of resuscitation and to reduce the seizure incidence within 3 days post-resuscitation. Findings of this preclinical study suggest that water electrolysis-derived 60% hydrogen gas may improve short-term outcomes in cardiogenic global brain hypoxia-ischemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 73-78 |
| Number of pages | 6 |
| Journal | Medical Gas Research |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1 2018 |
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Keywords
- cardiac arrest
- global brain ischemia
- high concentration hydrogen gas
- neurological deficit
- rat
- seizure
- water electrolysis
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Anesthesiology and Pain Medicine
Cite this
Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest. / Huang, Lei; Applegate, Richard Lee; Applegate, Patricia; Boling, Warren; Zhang, John.
In: Medical Gas Research, Vol. 8, No. 3, 01.07.2018, p. 73-78.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest
AU - Huang, Lei
AU - Applegate, Richard Lee
AU - Applegate, Patricia
AU - Boling, Warren
AU - Zhang, John
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Cardiogenic global brain hypoxia-ischemia is a devastating medical problem that is associated with unfavorable neurologic outcomes. Low dose hydrogen gas (up to 2.9%) has been shown to be neuroprotective in a variety of brain diseases. In the present study, we investigated the protective effect of water by electrolysis-derived high concentration hydrogen gas (60%) in a rat model of asphyxia induced-cardiac arrest and global brain hypoxia-ischemia. High concentration hydrogen gas was either administered starting 1 hour prior to cardiac arrest for 1 hour and starting 1 hour post-resuscitation for 1 hour (pre- & post-treatment) or starting 1 hour post-resuscitation for 2 hours (post-treatment). In animals subjected to 9 minutes of asphyxia, both therapeutic regimens tended to reduce the incidence of seizures and neurological deficits within 3 days post-resuscitation. In rats subjected to 11 minutes of asphyxia, significantly worse neurological deficits were observed compared to 9 minutes asphyxia, and pre- & post-treatment had a tendency to improve the success rate of resuscitation and to reduce the seizure incidence within 3 days post-resuscitation. Findings of this preclinical study suggest that water electrolysis-derived 60% hydrogen gas may improve short-term outcomes in cardiogenic global brain hypoxia-ischemia.
AB - Cardiogenic global brain hypoxia-ischemia is a devastating medical problem that is associated with unfavorable neurologic outcomes. Low dose hydrogen gas (up to 2.9%) has been shown to be neuroprotective in a variety of brain diseases. In the present study, we investigated the protective effect of water by electrolysis-derived high concentration hydrogen gas (60%) in a rat model of asphyxia induced-cardiac arrest and global brain hypoxia-ischemia. High concentration hydrogen gas was either administered starting 1 hour prior to cardiac arrest for 1 hour and starting 1 hour post-resuscitation for 1 hour (pre- & post-treatment) or starting 1 hour post-resuscitation for 2 hours (post-treatment). In animals subjected to 9 minutes of asphyxia, both therapeutic regimens tended to reduce the incidence of seizures and neurological deficits within 3 days post-resuscitation. In rats subjected to 11 minutes of asphyxia, significantly worse neurological deficits were observed compared to 9 minutes asphyxia, and pre- & post-treatment had a tendency to improve the success rate of resuscitation and to reduce the seizure incidence within 3 days post-resuscitation. Findings of this preclinical study suggest that water electrolysis-derived 60% hydrogen gas may improve short-term outcomes in cardiogenic global brain hypoxia-ischemia.
KW - cardiac arrest
KW - global brain ischemia
KW - high concentration hydrogen gas
KW - neurological deficit
KW - rat
KW - seizure
KW - water electrolysis
UR - http://www.scopus.com/inward/record.url?scp=85054196447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054196447&partnerID=8YFLogxK
U2 - 10.4103/2045-9912.241063
DO - 10.4103/2045-9912.241063
M3 - Article
AN - SCOPUS:85054196447
VL - 8
SP - 73
EP - 78
JO - Medical Gas Research
JF - Medical Gas Research
SN - 2045-9912
IS - 3
ER -