Abstract
Inhalation anesthetics are used widely for the anesthetic management of animals. They are unique among the anesthetic drugs because they are administered, and in large part removed from the body, via the lungs. The chemical structure of inhalation anesthetics and their physical properties determine their actions and safety of administration. The aim in administering an inhalation anesthetic to a patient is to achieve an adequate partial pressure or tension of anesthetic in the central nervous system to cause a desired level of CNS depression commensurate with the definition of general anesthesia. Recovery from inhalation anesthesia results from the elimination of anesthetic from the CNS. This chapter presents an indication of the extent of biotransformation of contemporary inhalation anesthetics. MAC is defined as the minimum alveolar concentration of an anesthetic at 1 atmosphere that produces immobility in 50% of subjects exposed to a supramaximal noxious stimulus.
| Original language | English (US) |
|---|---|
| Title of host publication | Veterinary Anesthesia and Analgesia |
| Subtitle of host publication | The Fifth Edition of Lumb and Jones |
| Publisher | wiley |
| Pages | 297-331 |
| Number of pages | 35 |
| ISBN (Electronic) | 9781119421375 |
| ISBN (Print) | 9781118526231 |
| DOIs | |
| State | Published - Apr 28 2017 |
Keywords
- Anesthetic elimination
- Biotransformation
- Central nervous system
- Inhalation anesthetics
- Minimum alveolar concentration
- Respiratory system
- Veterinary anesthesia
ASJC Scopus subject areas
- veterinary(all)