Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals

Carole Henry; Nai Ying Zheng; Min Huang; Alexandra Cabanov; Karla Thatcher Rojas; Kaval Kaur; Sarah F. Andrews; Anna Karin E. Palm; Yao Qing Chen; Yang Li; Katerina Hoskova; Henry A. Utset; Marcos C. Vieira; Jens Wrammert; Rafi Ahmed; Jeanne Holden-Wiltse; David J. Topham; John J. Treanor; Hildegund C. Ertl; Kenneth E. Schmader; Sarah Cobey; Florian Krammer; Scott E. Hensley; Harry Greenberg; Xiaosong He; Patrick C. Wilson

doi:10.1016/j.chom.2019.01.002

Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals

Carole Henry, Nai Ying Zheng, Min Huang, Alexandra Cabanov, Karla Thatcher Rojas, Kaval Kaur, Sarah F. Andrews, Anna Karin E. Palm, Yao Qing Chen, Yang Li, Katerina Hoskova, Henry A. Utset, Marcos C. Vieira, Jens Wrammert, Rafi Ahmed, Jeanne Holden-Wiltse, David J. Topham, John J. Treanor, Hildegund C. Ertl, Kenneth E. SchmaderSarah Cobey, Florian Krammer, Scott E. Hensley, Harry Greenberg, Xiaosong He, Patrick C. Wilson

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction of this population. A key aspect of antibody-mediated anti-influenza virus immunity is adaptation to antigenically distinct epitopes on emerging strains. We examined factors contributing to reduced influenza vaccine efficacy in the elderly and uncovered a dramatic reduction in the accumulation of de novo immunoglobulin gene somatic mutations upon vaccination. This reduction is associated with a significant decrease in the capacity of antibodies to target the viral glycoprotein, hemagglutinin (HA), and critical protective epitopes surrounding the HA receptor-binding domain. Immune escape by antigenic drift, in which viruses generate mutations in key antigenic epitopes, becomes highly exaggerated. Because of this reduced adaptability, most B cells activated in the elderly cohort target highly conserved but less potent epitopes. Given these findings, vaccines driving immunoglobulin gene somatic hypermutation should be a priority to protect elderly individuals.

Original language	English (US)
Pages (from-to)	357-366.e6
Journal	Cell Host and Microbe
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2019.01.002
State	Published - Mar 13 2019
Externally published	Yes

Keywords

elderly population
immunoglobulin genes
influenza vaccine
monoclonal antibodies

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2019.01.002

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Henry, C., Zheng, N. Y., Huang, M., Cabanov, A., Rojas, K. T., Kaur, K., Andrews, S. F., Palm, A. K. E., Chen, Y. Q., Li, Y., Hoskova, K., Utset, H. A., Vieira, M. C., Wrammert, J., Ahmed, R., Holden-Wiltse, J., Topham, D. J., Treanor, J. J., Ertl, H. C., ... Wilson, P. C. (2019). Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. Cell Host and Microbe, 25(3), 357-366.e6. https://doi.org/10.1016/j.chom.2019.01.002

Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. / Henry, Carole; Zheng, Nai Ying; Huang, Min; Cabanov, Alexandra; Rojas, Karla Thatcher; Kaur, Kaval; Andrews, Sarah F.; Palm, Anna Karin E.; Chen, Yao Qing; Li, Yang; Hoskova, Katerina; Utset, Henry A.; Vieira, Marcos C.; Wrammert, Jens; Ahmed, Rafi; Holden-Wiltse, Jeanne; Topham, David J.; Treanor, John J.; Ertl, Hildegund C.; Schmader, Kenneth E.; Cobey, Sarah; Krammer, Florian; Hensley, Scott E.; Greenberg, Harry; He, Xiaosong; Wilson, Patrick C.

In: Cell Host and Microbe, Vol. 25, No. 3, 13.03.2019, p. 357-366.e6.

Research output: Contribution to journal › Article › peer-review

Henry, C, Zheng, NY, Huang, M, Cabanov, A, Rojas, KT, Kaur, K, Andrews, SF, Palm, AKE, Chen, YQ, Li, Y, Hoskova, K, Utset, HA, Vieira, MC, Wrammert, J, Ahmed, R, Holden-Wiltse, J, Topham, DJ, Treanor, JJ, Ertl, HC, Schmader, KE, Cobey, S, Krammer, F, Hensley, SE, Greenberg, H, He, X & Wilson, PC 2019, 'Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals', Cell Host and Microbe, vol. 25, no. 3, pp. 357-366.e6. https://doi.org/10.1016/j.chom.2019.01.002

Henry, Carole ; Zheng, Nai Ying ; Huang, Min ; Cabanov, Alexandra ; Rojas, Karla Thatcher ; Kaur, Kaval ; Andrews, Sarah F. ; Palm, Anna Karin E. ; Chen, Yao Qing ; Li, Yang ; Hoskova, Katerina ; Utset, Henry A. ; Vieira, Marcos C. ; Wrammert, Jens ; Ahmed, Rafi ; Holden-Wiltse, Jeanne ; Topham, David J. ; Treanor, John J. ; Ertl, Hildegund C. ; Schmader, Kenneth E. ; Cobey, Sarah ; Krammer, Florian ; Hensley, Scott E. ; Greenberg, Harry ; He, Xiaosong ; Wilson, Patrick C. / Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. In: Cell Host and Microbe. 2019 ; Vol. 25, No. 3. pp. 357-366.e6.

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Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals

Abstract

Keywords

ASJC Scopus subject areas

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