Influences of lobar gray matter and white matter lesion load on cognition and mood

Susanne G. Mueller, Wendy J. Mack, Dan M Mungas, Joel H. Kramer, Valerie Cardenas-Nicolson, Helen Lavretsky, Maxwell Greene, Norbert Schuff, Helena C. Chui, Michael W. Weiner

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Depressed mood is a frequent co-morbidity of dementia suggesting that they might share a common neuropathological substrate. Gray matter (GM) atrophy and white matter lesions (WML) have been described in both conditions. Our aims were to determine the relationship of GM and WML with cognition and depressed mood in the same population. Structural brain images were obtained from 42 controls, 20 Alzheimer's disease (AD) patients and 32 subjects with cognitive impairment/dementia due to subcortical cerebrovascular disease (vascCIND/IVD). Images were segmented to obtain lobar GM, white matter and WML volumes. Lobar WML had a negative effect on GM in all lobes in controls, on frontal, parietal and occipital GM in AD and on frontal GM in vascCIND/IVD. Frontal, temporal and hippocampal GM were associated with cognitive functions and frontal WML load with depressed mood. Cognitive function is associated with GM atrophy and depressed mood is associated with frontal WML. This indicates that although both often occur together, depressed mood and cognitive impairment have different pathological correlates.

Original languageEnglish (US)
Pages (from-to)90-96
Number of pages7
JournalPsychiatry Research - Neuroimaging
Volume181
Issue number2
DOIs
StatePublished - Feb 28 2010

Fingerprint

Cognition
Atrophy
Dementia
Alzheimer Disease
Cerebrovascular Disorders
Gray Matter
White Matter
Morbidity
Brain
Population

Keywords

  • Cognition
  • Depression
  • Gray matter atrophy
  • Mood
  • MRI
  • White matter lesion

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Mueller, S. G., Mack, W. J., Mungas, D. M., Kramer, J. H., Cardenas-Nicolson, V., Lavretsky, H., ... Weiner, M. W. (2010). Influences of lobar gray matter and white matter lesion load on cognition and mood. Psychiatry Research - Neuroimaging, 181(2), 90-96. https://doi.org/10.1016/j.pscychresns.2009.08.002

Influences of lobar gray matter and white matter lesion load on cognition and mood. / Mueller, Susanne G.; Mack, Wendy J.; Mungas, Dan M; Kramer, Joel H.; Cardenas-Nicolson, Valerie; Lavretsky, Helen; Greene, Maxwell; Schuff, Norbert; Chui, Helena C.; Weiner, Michael W.

In: Psychiatry Research - Neuroimaging, Vol. 181, No. 2, 28.02.2010, p. 90-96.

Research output: Contribution to journalArticle

Mueller, SG, Mack, WJ, Mungas, DM, Kramer, JH, Cardenas-Nicolson, V, Lavretsky, H, Greene, M, Schuff, N, Chui, HC & Weiner, MW 2010, 'Influences of lobar gray matter and white matter lesion load on cognition and mood', Psychiatry Research - Neuroimaging, vol. 181, no. 2, pp. 90-96. https://doi.org/10.1016/j.pscychresns.2009.08.002
Mueller, Susanne G. ; Mack, Wendy J. ; Mungas, Dan M ; Kramer, Joel H. ; Cardenas-Nicolson, Valerie ; Lavretsky, Helen ; Greene, Maxwell ; Schuff, Norbert ; Chui, Helena C. ; Weiner, Michael W. / Influences of lobar gray matter and white matter lesion load on cognition and mood. In: Psychiatry Research - Neuroimaging. 2010 ; Vol. 181, No. 2. pp. 90-96.
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