Influences of calorie restriction and age on energy expenditure in the rhesus monkey

Aarthi Raman, Jon J Ramsey, Joseph W. Kemnitz, Scott T. Baum, Wendy Newton, Ricki J. Colman, Richard Weindruch, Mark T. Beasley, Dale A. Schoeller

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Caloric restriction (CR) is known to retard the aging process, and a marker of aging is decreased energy expenditure (EE). To assess longitudinal effects of CR on EE in rhesus monkeys (Macaca mulatta), data from 41 males (M) and 26 females (F) subjected to 9 or 15 yr of CR were studied. EE and body composition of monkeys 11-28 yr of age were measured using indirect calorimetry and dual X-ray absorptiometry. Total EE (24-h EE) was divided into daytime (day EE), nighttime (night EE), and daytime minus nighttime (D - N EE). M calorie-restricted monkeys showed a lower 24-h EE (means ± SD = 568 ± 96 kcal/day, P < 0.0001) than controls (C; 630 ± 129 kcal/day). Calorie-restricted M had a lower night EE (difference = 36 kcal P < 0.0001) compared with C M, but after adjusting for FFM and FM, night EE was not different between calorie-restricted and C males (P = 0.72). The 24-h EE decreased with age (13 kcal decrease/yr, P < 0.0001), but there was no difference between CR and C. Adjusted for FFM and FM, D - N EE decreased with age (9 kcal/yr, P < 0.0001), with no interaction with age (P = 0.72). The F were compared with age-matched M selected from the male cohort. F had a lower 24-h EE (496 ± 84 kcal/day) than M (636 ± 139 kcal/day) (P < 0.0001). Adjusting for FFM and FM, night EE was lower in F compared with M (difference = 18 kcal, P = 0.077). Night EE did not differ between calorie-restricted and C younger monkeys after adjusting for FFM and FM. In conclusion, CR did not alter the age-related decrease in EE with CR.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume292
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Dietary restriction
  • Indirect calorimetry
  • Metabolic rate

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

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    Raman, A., Ramsey, J. J., Kemnitz, J. W., Baum, S. T., Newton, W., Colman, R. J., Weindruch, R., Beasley, M. T., & Schoeller, D. A. (2007). Influences of calorie restriction and age on energy expenditure in the rhesus monkey. American Journal of Physiology - Endocrinology and Metabolism, 292(1). https://doi.org/10.1152/ajpendo.00127.2006