Abstract
Background. Variation at the apolipoprotein E (apo E) locus influence lipid and lipoprotein levels in the normal population, and is associated with premature coronary artery disease. Patients with end-stage kidney disease or undergoing dialysis treatment are particularly prone to develop accelerated atherosclerosis. Methods. To evaluate the influence of genetic variation at the apo E locus, apo E genotypes and serum lipid and lipoprotein levels were measured in 51 subjects undergoing continuous ambulatory peritoneal dialysis (CAPD). Results. The distribution of apo E phenotypes and apo E allelic frequency among the CAPD subjects (ε2 0.049; ε3 0.745; ε4 0.206) corresponded to the healthy Swedish population. In the CAPD subjects, total serum and LDL cholesterol levels were high (6.7 ± 1.5 mmol/l and 4.2 ± 1.3 mmol/l respectively) and HDL cholesterol levels were low (1.2 ± 0.5 mmol/l). When directly comparing the two major apo E groups, E 3/3 subjects (n = 30) and E4/3 and 4/4 subjects, ε4-carriers, (n = 16), LDL cholesterol levels were significantly higher among ε4-carriers (4.8 ± 1.1 vs 4.0 ± 1.2 mmol/l, P < 0.03), but total serum cholesterol levels was not higher among the ε4-carriers (7.3 ± 1.3 vs 6.5 ± 1.5 mmol/l, P < 0.08). Serum triglycerides or HDL cholesterol levels did not differ significantly between ε3-homozygotes and ε4-carriers. Conclusions. The results demonstrate a strong effect of variation of the apo E locus on LDL cholesterol levels in CAPD subjects, suggesting that ε4-carriers may be more susceptible to accelerated development of atherosclerosis in this condition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 141-144 |
| Number of pages | 4 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1997 |
| Externally published | Yes |
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Keywords
- Apolipoprotein E
- Atherosclerosis
- Kidney disease
- LDL cholesterol
- Peritoneal dialysis
ASJC Scopus subject areas
- Nephrology
- Transplantation
Cite this
Influence of variation at the apolipoprotein E locus on lipid and lipoprotein levels in CAPD patients. / Eggertsen, G.; Heimbürger, O.; Stenvinkel, P.; Berglund, Lars.
In: Nephrology Dialysis Transplantation, Vol. 12, No. 1, 01.1997, p. 141-144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of variation at the apolipoprotein E locus on lipid and lipoprotein levels in CAPD patients
AU - Eggertsen, G.
AU - Heimbürger, O.
AU - Stenvinkel, P.
AU - Berglund, Lars
PY - 1997/1
Y1 - 1997/1
N2 - Background. Variation at the apolipoprotein E (apo E) locus influence lipid and lipoprotein levels in the normal population, and is associated with premature coronary artery disease. Patients with end-stage kidney disease or undergoing dialysis treatment are particularly prone to develop accelerated atherosclerosis. Methods. To evaluate the influence of genetic variation at the apo E locus, apo E genotypes and serum lipid and lipoprotein levels were measured in 51 subjects undergoing continuous ambulatory peritoneal dialysis (CAPD). Results. The distribution of apo E phenotypes and apo E allelic frequency among the CAPD subjects (ε2 0.049; ε3 0.745; ε4 0.206) corresponded to the healthy Swedish population. In the CAPD subjects, total serum and LDL cholesterol levels were high (6.7 ± 1.5 mmol/l and 4.2 ± 1.3 mmol/l respectively) and HDL cholesterol levels were low (1.2 ± 0.5 mmol/l). When directly comparing the two major apo E groups, E 3/3 subjects (n = 30) and E4/3 and 4/4 subjects, ε4-carriers, (n = 16), LDL cholesterol levels were significantly higher among ε4-carriers (4.8 ± 1.1 vs 4.0 ± 1.2 mmol/l, P < 0.03), but total serum cholesterol levels was not higher among the ε4-carriers (7.3 ± 1.3 vs 6.5 ± 1.5 mmol/l, P < 0.08). Serum triglycerides or HDL cholesterol levels did not differ significantly between ε3-homozygotes and ε4-carriers. Conclusions. The results demonstrate a strong effect of variation of the apo E locus on LDL cholesterol levels in CAPD subjects, suggesting that ε4-carriers may be more susceptible to accelerated development of atherosclerosis in this condition.
AB - Background. Variation at the apolipoprotein E (apo E) locus influence lipid and lipoprotein levels in the normal population, and is associated with premature coronary artery disease. Patients with end-stage kidney disease or undergoing dialysis treatment are particularly prone to develop accelerated atherosclerosis. Methods. To evaluate the influence of genetic variation at the apo E locus, apo E genotypes and serum lipid and lipoprotein levels were measured in 51 subjects undergoing continuous ambulatory peritoneal dialysis (CAPD). Results. The distribution of apo E phenotypes and apo E allelic frequency among the CAPD subjects (ε2 0.049; ε3 0.745; ε4 0.206) corresponded to the healthy Swedish population. In the CAPD subjects, total serum and LDL cholesterol levels were high (6.7 ± 1.5 mmol/l and 4.2 ± 1.3 mmol/l respectively) and HDL cholesterol levels were low (1.2 ± 0.5 mmol/l). When directly comparing the two major apo E groups, E 3/3 subjects (n = 30) and E4/3 and 4/4 subjects, ε4-carriers, (n = 16), LDL cholesterol levels were significantly higher among ε4-carriers (4.8 ± 1.1 vs 4.0 ± 1.2 mmol/l, P < 0.03), but total serum cholesterol levels was not higher among the ε4-carriers (7.3 ± 1.3 vs 6.5 ± 1.5 mmol/l, P < 0.08). Serum triglycerides or HDL cholesterol levels did not differ significantly between ε3-homozygotes and ε4-carriers. Conclusions. The results demonstrate a strong effect of variation of the apo E locus on LDL cholesterol levels in CAPD subjects, suggesting that ε4-carriers may be more susceptible to accelerated development of atherosclerosis in this condition.
KW - Apolipoprotein E
KW - Atherosclerosis
KW - Kidney disease
KW - LDL cholesterol
KW - Peritoneal dialysis
UR - http://www.scopus.com/inward/record.url?scp=0031013045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031013045&partnerID=8YFLogxK
U2 - 10.1093/ndt/12.1.141
DO - 10.1093/ndt/12.1.141
M3 - Article
C2 - 9027789
AN - SCOPUS:0031013045
VL - 12
SP - 141
EP - 144
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
SN - 0931-0509
IS - 1
ER -