Influence of tumor cell proliferation and sex-hormone receptors on effectiveness of radiation therapy for dogs with incompletely resected meningiomas

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Abstract

Objective - To assess the influence of tumor cell proliferation and sex-hormone receptors on the efficacy of megavoltage irradiation for dogs with incompletely resected meningiomas. Design - Longitudinal clinical trial. Animals - 20 dogs with incompletely resected intracranial meningiomas. Procedure - Dogs were treated with 48 Gy of radiation administered 3 times per week on an alternate-day schedule of 4 Gy/fraction for 4 weeks, using bilateral parallel-opposed fields. Results - Tumor proliferative fraction measured by immunohistochemical detection of proliferating cell nuclear antigen (PFPCNA index) ranged from 10 to 42% (median, 24%). Progesterone receptor immunoreactivity was detected in 70% of tumors. Estrogen receptor immunoreactivity was not detected. An inverse correlation was found between detection of progesterone receptors and the PFPCNA index. The overall 2-year progression-free survival (PFS) rate was 68%. The only prognostic factor that significantly affected PFS rate was the PFPCNA index. The 2-year PFS was 42% for tumors with a high PFPCNA index (value ≥ 24%) and 91 % for tumors with a low PFPCNA index (value < 24%). Tumors with a high PFPCNA index were 9.1 times as likely to recur as were tumors with a low PFPCNA index. Conclusions and Clinical Relevance - This study confirms the value of irradiation for dogs with incompletely resected meningiomas. Prognostic value of the PFPCNA index suggests that duration of treatment and interval from surgery to start of irradiation may affect outcome. Loss of progesterone receptors in some tumors may be responsible for an increase in PFPCNA index and may indirectly affect prognosis after radiation therapy.

Original languageEnglish (US)
Pages (from-to)701-707
Number of pages7
JournalJournal of the American Veterinary Medical Association
Volume216
Issue number5
StatePublished - Mar 1 2000

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therapy dogs
Gonadal Steroid Hormones
Meningioma
radiotherapy
cell proliferation
Radiotherapy
Cell Proliferation
Dogs
neoplasms
Neoplasms
Progesterone Receptors
Disease-Free Survival
irradiation
dogs
survival rate
proliferating cell nuclear antigen
Radiation Dosage
sex hormone receptors
neoplasm cells
Proliferating Cell Nuclear Antigen

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{5049ad84fd2e4aee9645ad7da412f2ba,
title = "Influence of tumor cell proliferation and sex-hormone receptors on effectiveness of radiation therapy for dogs with incompletely resected meningiomas",
abstract = "Objective - To assess the influence of tumor cell proliferation and sex-hormone receptors on the efficacy of megavoltage irradiation for dogs with incompletely resected meningiomas. Design - Longitudinal clinical trial. Animals - 20 dogs with incompletely resected intracranial meningiomas. Procedure - Dogs were treated with 48 Gy of radiation administered 3 times per week on an alternate-day schedule of 4 Gy/fraction for 4 weeks, using bilateral parallel-opposed fields. Results - Tumor proliferative fraction measured by immunohistochemical detection of proliferating cell nuclear antigen (PFPCNA index) ranged from 10 to 42{\%} (median, 24{\%}). Progesterone receptor immunoreactivity was detected in 70{\%} of tumors. Estrogen receptor immunoreactivity was not detected. An inverse correlation was found between detection of progesterone receptors and the PFPCNA index. The overall 2-year progression-free survival (PFS) rate was 68{\%}. The only prognostic factor that significantly affected PFS rate was the PFPCNA index. The 2-year PFS was 42{\%} for tumors with a high PFPCNA index (value ≥ 24{\%}) and 91 {\%} for tumors with a low PFPCNA index (value < 24{\%}). Tumors with a high PFPCNA index were 9.1 times as likely to recur as were tumors with a low PFPCNA index. Conclusions and Clinical Relevance - This study confirms the value of irradiation for dogs with incompletely resected meningiomas. Prognostic value of the PFPCNA index suggests that duration of treatment and interval from surgery to start of irradiation may affect outcome. Loss of progesterone receptors in some tumors may be responsible for an increase in PFPCNA index and may indirectly affect prognosis after radiation therapy.",
author = "Theon, {Alain P} and Lecouteur, {Richard A} and Carr, {Elizabeth A.} and Griffey, {Stephen M}",
year = "2000",
month = "3",
day = "1",
language = "English (US)",
volume = "216",
pages = "701--707",
journal = "Journal of the American Veterinary Medical Association",
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TY - JOUR

T1 - Influence of tumor cell proliferation and sex-hormone receptors on effectiveness of radiation therapy for dogs with incompletely resected meningiomas

AU - Theon, Alain P

AU - Lecouteur, Richard A

AU - Carr, Elizabeth A.

AU - Griffey, Stephen M

PY - 2000/3/1

Y1 - 2000/3/1

N2 - Objective - To assess the influence of tumor cell proliferation and sex-hormone receptors on the efficacy of megavoltage irradiation for dogs with incompletely resected meningiomas. Design - Longitudinal clinical trial. Animals - 20 dogs with incompletely resected intracranial meningiomas. Procedure - Dogs were treated with 48 Gy of radiation administered 3 times per week on an alternate-day schedule of 4 Gy/fraction for 4 weeks, using bilateral parallel-opposed fields. Results - Tumor proliferative fraction measured by immunohistochemical detection of proliferating cell nuclear antigen (PFPCNA index) ranged from 10 to 42% (median, 24%). Progesterone receptor immunoreactivity was detected in 70% of tumors. Estrogen receptor immunoreactivity was not detected. An inverse correlation was found between detection of progesterone receptors and the PFPCNA index. The overall 2-year progression-free survival (PFS) rate was 68%. The only prognostic factor that significantly affected PFS rate was the PFPCNA index. The 2-year PFS was 42% for tumors with a high PFPCNA index (value ≥ 24%) and 91 % for tumors with a low PFPCNA index (value < 24%). Tumors with a high PFPCNA index were 9.1 times as likely to recur as were tumors with a low PFPCNA index. Conclusions and Clinical Relevance - This study confirms the value of irradiation for dogs with incompletely resected meningiomas. Prognostic value of the PFPCNA index suggests that duration of treatment and interval from surgery to start of irradiation may affect outcome. Loss of progesterone receptors in some tumors may be responsible for an increase in PFPCNA index and may indirectly affect prognosis after radiation therapy.

AB - Objective - To assess the influence of tumor cell proliferation and sex-hormone receptors on the efficacy of megavoltage irradiation for dogs with incompletely resected meningiomas. Design - Longitudinal clinical trial. Animals - 20 dogs with incompletely resected intracranial meningiomas. Procedure - Dogs were treated with 48 Gy of radiation administered 3 times per week on an alternate-day schedule of 4 Gy/fraction for 4 weeks, using bilateral parallel-opposed fields. Results - Tumor proliferative fraction measured by immunohistochemical detection of proliferating cell nuclear antigen (PFPCNA index) ranged from 10 to 42% (median, 24%). Progesterone receptor immunoreactivity was detected in 70% of tumors. Estrogen receptor immunoreactivity was not detected. An inverse correlation was found between detection of progesterone receptors and the PFPCNA index. The overall 2-year progression-free survival (PFS) rate was 68%. The only prognostic factor that significantly affected PFS rate was the PFPCNA index. The 2-year PFS was 42% for tumors with a high PFPCNA index (value ≥ 24%) and 91 % for tumors with a low PFPCNA index (value < 24%). Tumors with a high PFPCNA index were 9.1 times as likely to recur as were tumors with a low PFPCNA index. Conclusions and Clinical Relevance - This study confirms the value of irradiation for dogs with incompletely resected meningiomas. Prognostic value of the PFPCNA index suggests that duration of treatment and interval from surgery to start of irradiation may affect outcome. Loss of progesterone receptors in some tumors may be responsible for an increase in PFPCNA index and may indirectly affect prognosis after radiation therapy.

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