Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection

Debanjan Mukhopadhyay, David Arranz-Solís, Jeroen P.J. Saeij

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Toxoplasma gondii is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection. These differential disease patterns are strongly influenced by both host- and parasite-specific genetic factors. In this review, we discuss how the clinical outcome of toxoplasmosis varies between hosts and the role of different immune genes and parasite virulence factors, with a special emphasis on Toxoplasma-induced ileitis and encephalitis.

Original languageEnglish (US)
Article number580425
JournalFrontiers in Cellular and Infection Microbiology
Volume10
DOIs
StatePublished - Oct 15 2020

Keywords

  • encephalitis
  • ileitis
  • immune response
  • strain
  • Toxoplasma
  • virulence factor

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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