Influence of stimulants on electrodermal studies in fragile X syndrome

Randi J Hagerman, Lucy J. Miller, Jude McGrath-Clarke, Karen Riley, Edward Goldson, Susan W. Harris, Jody Simon, Kelly Church, Julie Bonnell, Todd C. Ognibene, Daniel N. McIntosh

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is seen in the majority of children with Fragile X Syndrome (FraX). Previous work has documented an enhanced sweat response to stimuli in children with FraX compared to controls utilizing electrodermal response (EDR) measures. The present study assesses the EDRs both on and off stimulants in 19 children with ADHD and FraX compared to 17 age- and IQ-matched control patients with ADHD and developmental delays. Although the baseline EDRs were comparable between FraX patients and controls, the patients with FraX had a significant decrease in EDR amplitude and number of peaks when treated with stimulants compared to controls. This suggests that patients with FraX are more responsive to the enhancement of inhibitory systems that occur with stimulant use for ADHD. The use of a quantifiable measure, such as EDR, is recommended in future studies of treatment efficacy.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalMicroscopy Research and Technique
Volume57
Issue number3
DOIs
StatePublished - May 1 2002

Fingerprint

stimulants
Fragile X Syndrome
galvanic skin response
Galvanic Skin Response
Attention Deficit Disorder with Hyperactivity
disorders
sweat
Sweat
stimuli
augmentation

Keywords

  • Adderall
  • ADHD
  • Autonomic
  • Methylphenidate

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Hagerman, R. J., Miller, L. J., McGrath-Clarke, J., Riley, K., Goldson, E., Harris, S. W., ... McIntosh, D. N. (2002). Influence of stimulants on electrodermal studies in fragile X syndrome. Microscopy Research and Technique, 57(3), 168-173. https://doi.org/10.1002/jemt.10067

Influence of stimulants on electrodermal studies in fragile X syndrome. / Hagerman, Randi J; Miller, Lucy J.; McGrath-Clarke, Jude; Riley, Karen; Goldson, Edward; Harris, Susan W.; Simon, Jody; Church, Kelly; Bonnell, Julie; Ognibene, Todd C.; McIntosh, Daniel N.

In: Microscopy Research and Technique, Vol. 57, No. 3, 01.05.2002, p. 168-173.

Research output: Contribution to journalArticle

Hagerman, RJ, Miller, LJ, McGrath-Clarke, J, Riley, K, Goldson, E, Harris, SW, Simon, J, Church, K, Bonnell, J, Ognibene, TC & McIntosh, DN 2002, 'Influence of stimulants on electrodermal studies in fragile X syndrome', Microscopy Research and Technique, vol. 57, no. 3, pp. 168-173. https://doi.org/10.1002/jemt.10067
Hagerman, Randi J ; Miller, Lucy J. ; McGrath-Clarke, Jude ; Riley, Karen ; Goldson, Edward ; Harris, Susan W. ; Simon, Jody ; Church, Kelly ; Bonnell, Julie ; Ognibene, Todd C. ; McIntosh, Daniel N. / Influence of stimulants on electrodermal studies in fragile X syndrome. In: Microscopy Research and Technique. 2002 ; Vol. 57, No. 3. pp. 168-173.
@article{cce78bd08aed4e93bf3a65b7ba1fe428,
title = "Influence of stimulants on electrodermal studies in fragile X syndrome",
abstract = "Attention Deficit Hyperactivity Disorder (ADHD) is seen in the majority of children with Fragile X Syndrome (FraX). Previous work has documented an enhanced sweat response to stimuli in children with FraX compared to controls utilizing electrodermal response (EDR) measures. The present study assesses the EDRs both on and off stimulants in 19 children with ADHD and FraX compared to 17 age- and IQ-matched control patients with ADHD and developmental delays. Although the baseline EDRs were comparable between FraX patients and controls, the patients with FraX had a significant decrease in EDR amplitude and number of peaks when treated with stimulants compared to controls. This suggests that patients with FraX are more responsive to the enhancement of inhibitory systems that occur with stimulant use for ADHD. The use of a quantifiable measure, such as EDR, is recommended in future studies of treatment efficacy.",
keywords = "Adderall, ADHD, Autonomic, Methylphenidate",
author = "Hagerman, {Randi J} and Miller, {Lucy J.} and Jude McGrath-Clarke and Karen Riley and Edward Goldson and Harris, {Susan W.} and Jody Simon and Kelly Church and Julie Bonnell and Ognibene, {Todd C.} and McIntosh, {Daniel N.}",
year = "2002",
month = "5",
day = "1",
doi = "10.1002/jemt.10067",
language = "English (US)",
volume = "57",
pages = "168--173",
journal = "Microscopy Research and Technique",
issn = "1059-910X",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Influence of stimulants on electrodermal studies in fragile X syndrome

AU - Hagerman, Randi J

AU - Miller, Lucy J.

AU - McGrath-Clarke, Jude

AU - Riley, Karen

AU - Goldson, Edward

AU - Harris, Susan W.

AU - Simon, Jody

AU - Church, Kelly

AU - Bonnell, Julie

AU - Ognibene, Todd C.

AU - McIntosh, Daniel N.

PY - 2002/5/1

Y1 - 2002/5/1

N2 - Attention Deficit Hyperactivity Disorder (ADHD) is seen in the majority of children with Fragile X Syndrome (FraX). Previous work has documented an enhanced sweat response to stimuli in children with FraX compared to controls utilizing electrodermal response (EDR) measures. The present study assesses the EDRs both on and off stimulants in 19 children with ADHD and FraX compared to 17 age- and IQ-matched control patients with ADHD and developmental delays. Although the baseline EDRs were comparable between FraX patients and controls, the patients with FraX had a significant decrease in EDR amplitude and number of peaks when treated with stimulants compared to controls. This suggests that patients with FraX are more responsive to the enhancement of inhibitory systems that occur with stimulant use for ADHD. The use of a quantifiable measure, such as EDR, is recommended in future studies of treatment efficacy.

AB - Attention Deficit Hyperactivity Disorder (ADHD) is seen in the majority of children with Fragile X Syndrome (FraX). Previous work has documented an enhanced sweat response to stimuli in children with FraX compared to controls utilizing electrodermal response (EDR) measures. The present study assesses the EDRs both on and off stimulants in 19 children with ADHD and FraX compared to 17 age- and IQ-matched control patients with ADHD and developmental delays. Although the baseline EDRs were comparable between FraX patients and controls, the patients with FraX had a significant decrease in EDR amplitude and number of peaks when treated with stimulants compared to controls. This suggests that patients with FraX are more responsive to the enhancement of inhibitory systems that occur with stimulant use for ADHD. The use of a quantifiable measure, such as EDR, is recommended in future studies of treatment efficacy.

KW - Adderall

KW - ADHD

KW - Autonomic

KW - Methylphenidate

UR - http://www.scopus.com/inward/record.url?scp=18344387333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344387333&partnerID=8YFLogxK

U2 - 10.1002/jemt.10067

DO - 10.1002/jemt.10067

M3 - Article

C2 - 12112453

AN - SCOPUS:18344387333

VL - 57

SP - 168

EP - 173

JO - Microscopy Research and Technique

JF - Microscopy Research and Technique

SN - 1059-910X

IS - 3

ER -