Influence of stimulants on electrodermal studies in fragile X syndrome

Randi J Hagerman, Lucy J. Miller, Jude McGrath-Clarke, Karen Riley, Edward Goldson, Susan W. Harris, Jody Simon, Kelly Church, Julie Bonnell, Todd C. Ognibene, Daniel N. McIntosh

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Attention Deficit Hyperactivity Disorder (ADHD) is seen in the majority of children with Fragile X Syndrome (FraX). Previous work has documented an enhanced sweat response to stimuli in children with FraX compared to controls utilizing electrodermal response (EDR) measures. The present study assesses the EDRs both on and off stimulants in 19 children with ADHD and FraX compared to 17 age- and IQ-matched control patients with ADHD and developmental delays. Although the baseline EDRs were comparable between FraX patients and controls, the patients with FraX had a significant decrease in EDR amplitude and number of peaks when treated with stimulants compared to controls. This suggests that patients with FraX are more responsive to the enhancement of inhibitory systems that occur with stimulant use for ADHD. The use of a quantifiable measure, such as EDR, is recommended in future studies of treatment efficacy.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalMicroscopy Research and Technique
Issue number3
StatePublished - May 1 2002


  • Adderall
  • ADHD
  • Autonomic
  • Methylphenidate

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation


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