Influence of season and location on pulmonary response to California's San Joaquin Valley airborne particulate matter

Laurel E. Plummer, Walter Ham, Michael J. Kleeman, Anthony Wexler, Kent E Pinkerton

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Season and location have documented impacts on particulate matter (PM)-induced morbidity and mortality. Seasonal and regional influences on the physical and chemical properties of PM 2.5 (also known as fine/ultrafine PM) contribute to differences in exposure burden and adverse respiratory health outcomes experienced in California's San Joaquin Valley (SJV), which ranks among the worst in the nation for PM pollution. Current regulations are driven by the association between mass concentrations and adverse health outcomes. However, this association is difficult to reproduce in toxicological studies and suggests a role for other parameters, such as chemical composition, involved in PM-induced adverse pulmonary health effects. Pulmonary toxicity of summer/winter and rural/urban SJV PM was evaluated given the unique geography, metereology and sources of the region. Healthy juvenile male mice inhaled summer/winter and urban/rural concentrated ambient PM (CAP) or ambient PM for 6 h/d for 10 d, and pulmonary inflammatory responses were measured 48 h postexposure. Exposure concentrations ranged from 10 to 20 μg/m 3 for ambient air control mice and from 86 to 284 μg/m 3. Mice exposed to rural but not urban CAP, displayed significant neutrophil influx that was more than 50-fold greater than control levels, which ranged from 21 to 60 neutrophils/ml for all experiments. Pulmonary neutrophilic inflammation was measured despite lower CAP concentrations in the rural compared to the urban location and in the absence of cytotoxicity, oxidative stress, or elevations in cytokine and chemokines expression. Further, the inflammatory responses induced by rural winter CAP were associated with the highest levels of organic carbon (OC) and nitrates (NO 3 -). Evidence indicates that regional/seasonal influences on PM chemical composition rather than PM mass may be associated with increased PM-induced adverse health effects.

Original languageEnglish (US)
Pages (from-to)253-271
Number of pages19
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume75
Issue number5
DOIs
StatePublished - Mar 1 2012

Fingerprint

Particulate Matter
Lung
Health
Neutrophils
Association reactions
Geography
Oxidative stress
Level control
Cytotoxicity
Organic carbon
Chemical analysis
Chemokines
Nitrates
Toxicology
Chemical properties
Toxicity
Pneumonia
Oxidative Stress
Pollution
Carbon

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Influence of season and location on pulmonary response to California's San Joaquin Valley airborne particulate matter. / Plummer, Laurel E.; Ham, Walter; Kleeman, Michael J.; Wexler, Anthony; Pinkerton, Kent E.

In: Journal of Toxicology and Environmental Health - Part A: Current Issues, Vol. 75, No. 5, 01.03.2012, p. 253-271.

Research output: Contribution to journalArticle

@article{086f00c38eb74acc8cf24ac0033ecdf0,
title = "Influence of season and location on pulmonary response to California's San Joaquin Valley airborne particulate matter",
abstract = "Season and location have documented impacts on particulate matter (PM)-induced morbidity and mortality. Seasonal and regional influences on the physical and chemical properties of PM 2.5 (also known as fine/ultrafine PM) contribute to differences in exposure burden and adverse respiratory health outcomes experienced in California's San Joaquin Valley (SJV), which ranks among the worst in the nation for PM pollution. Current regulations are driven by the association between mass concentrations and adverse health outcomes. However, this association is difficult to reproduce in toxicological studies and suggests a role for other parameters, such as chemical composition, involved in PM-induced adverse pulmonary health effects. Pulmonary toxicity of summer/winter and rural/urban SJV PM was evaluated given the unique geography, metereology and sources of the region. Healthy juvenile male mice inhaled summer/winter and urban/rural concentrated ambient PM (CAP) or ambient PM for 6 h/d for 10 d, and pulmonary inflammatory responses were measured 48 h postexposure. Exposure concentrations ranged from 10 to 20 μg/m 3 for ambient air control mice and from 86 to 284 μg/m 3. Mice exposed to rural but not urban CAP, displayed significant neutrophil influx that was more than 50-fold greater than control levels, which ranged from 21 to 60 neutrophils/ml for all experiments. Pulmonary neutrophilic inflammation was measured despite lower CAP concentrations in the rural compared to the urban location and in the absence of cytotoxicity, oxidative stress, or elevations in cytokine and chemokines expression. Further, the inflammatory responses induced by rural winter CAP were associated with the highest levels of organic carbon (OC) and nitrates (NO 3 -). Evidence indicates that regional/seasonal influences on PM chemical composition rather than PM mass may be associated with increased PM-induced adverse health effects.",
author = "Plummer, {Laurel E.} and Walter Ham and Kleeman, {Michael J.} and Anthony Wexler and Pinkerton, {Kent E}",
year = "2012",
month = "3",
day = "1",
doi = "10.1080/15287394.2012.640102",
language = "English (US)",
volume = "75",
pages = "253--271",
journal = "Journal of Toxicology and Environmental Health - Part A: Current Issues",
issn = "1528-7394",
publisher = "Taylor and Francis Ltd.",
number = "5",

}

TY - JOUR

T1 - Influence of season and location on pulmonary response to California's San Joaquin Valley airborne particulate matter

AU - Plummer, Laurel E.

AU - Ham, Walter

AU - Kleeman, Michael J.

AU - Wexler, Anthony

AU - Pinkerton, Kent E

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Season and location have documented impacts on particulate matter (PM)-induced morbidity and mortality. Seasonal and regional influences on the physical and chemical properties of PM 2.5 (also known as fine/ultrafine PM) contribute to differences in exposure burden and adverse respiratory health outcomes experienced in California's San Joaquin Valley (SJV), which ranks among the worst in the nation for PM pollution. Current regulations are driven by the association between mass concentrations and adverse health outcomes. However, this association is difficult to reproduce in toxicological studies and suggests a role for other parameters, such as chemical composition, involved in PM-induced adverse pulmonary health effects. Pulmonary toxicity of summer/winter and rural/urban SJV PM was evaluated given the unique geography, metereology and sources of the region. Healthy juvenile male mice inhaled summer/winter and urban/rural concentrated ambient PM (CAP) or ambient PM for 6 h/d for 10 d, and pulmonary inflammatory responses were measured 48 h postexposure. Exposure concentrations ranged from 10 to 20 μg/m 3 for ambient air control mice and from 86 to 284 μg/m 3. Mice exposed to rural but not urban CAP, displayed significant neutrophil influx that was more than 50-fold greater than control levels, which ranged from 21 to 60 neutrophils/ml for all experiments. Pulmonary neutrophilic inflammation was measured despite lower CAP concentrations in the rural compared to the urban location and in the absence of cytotoxicity, oxidative stress, or elevations in cytokine and chemokines expression. Further, the inflammatory responses induced by rural winter CAP were associated with the highest levels of organic carbon (OC) and nitrates (NO 3 -). Evidence indicates that regional/seasonal influences on PM chemical composition rather than PM mass may be associated with increased PM-induced adverse health effects.

AB - Season and location have documented impacts on particulate matter (PM)-induced morbidity and mortality. Seasonal and regional influences on the physical and chemical properties of PM 2.5 (also known as fine/ultrafine PM) contribute to differences in exposure burden and adverse respiratory health outcomes experienced in California's San Joaquin Valley (SJV), which ranks among the worst in the nation for PM pollution. Current regulations are driven by the association between mass concentrations and adverse health outcomes. However, this association is difficult to reproduce in toxicological studies and suggests a role for other parameters, such as chemical composition, involved in PM-induced adverse pulmonary health effects. Pulmonary toxicity of summer/winter and rural/urban SJV PM was evaluated given the unique geography, metereology and sources of the region. Healthy juvenile male mice inhaled summer/winter and urban/rural concentrated ambient PM (CAP) or ambient PM for 6 h/d for 10 d, and pulmonary inflammatory responses were measured 48 h postexposure. Exposure concentrations ranged from 10 to 20 μg/m 3 for ambient air control mice and from 86 to 284 μg/m 3. Mice exposed to rural but not urban CAP, displayed significant neutrophil influx that was more than 50-fold greater than control levels, which ranged from 21 to 60 neutrophils/ml for all experiments. Pulmonary neutrophilic inflammation was measured despite lower CAP concentrations in the rural compared to the urban location and in the absence of cytotoxicity, oxidative stress, or elevations in cytokine and chemokines expression. Further, the inflammatory responses induced by rural winter CAP were associated with the highest levels of organic carbon (OC) and nitrates (NO 3 -). Evidence indicates that regional/seasonal influences on PM chemical composition rather than PM mass may be associated with increased PM-induced adverse health effects.

UR - http://www.scopus.com/inward/record.url?scp=84859175490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859175490&partnerID=8YFLogxK

U2 - 10.1080/15287394.2012.640102

DO - 10.1080/15287394.2012.640102

M3 - Article

C2 - 22409489

AN - SCOPUS:84859175490

VL - 75

SP - 253

EP - 271

JO - Journal of Toxicology and Environmental Health - Part A: Current Issues

JF - Journal of Toxicology and Environmental Health - Part A: Current Issues

SN - 1528-7394

IS - 5

ER -