Influence of Pravastatin on Hepatic Metabolism of Cholesterol

Marc Hellerstein, Eva Reihnér, Mats Rudling, Dagny Ståhlberg, Lars Berglund, Staffan Ewerth, Ingemar Björkhem, Kurt Einarsson, bo Angelin

Research output: Contribution to journalLetter

Abstract

To the Editor: Reihnér et al. (July 26 issue)1 should be commended for their interesting study and their methodologic groundwork.2 , 3 It would be premature, however, to draw conclusions about the relative quantitative roles of inhibition of cholesterol synthesis and stimulation of uptake mediated by low-density lipoprotein receptors in the hypocholesterolemic effects of pravastatin. Reihnér et al. did not measure the rate of cholesterol synthesis directly but estimated it indirectly from the ratio of serum free lathosterol to free cholesterol. This technique is based on rather simplistic assumptions: that cellular steroid concentrations must all exhibit a simple metabolite crossover4 at 3-hydroxy-3-methylglutaryl-coenzyme. . .

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume324
Issue number2
DOIs
StatePublished - Jan 10 1991
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Hellerstein, M., Reihnér, E., Rudling, M., Ståhlberg, D., Berglund, L., Ewerth, S., Björkhem, I., Einarsson, K., & Angelin, B. (1991). Influence of Pravastatin on Hepatic Metabolism of Cholesterol. New England Journal of Medicine, 324(2). https://doi.org/10.1056/NEJM199101103240213