Influence of pirfenidone on airway hyperresponsiveness and inflammation in a Brown-Norway rat model of asthma

Jim K. Mansoor, Kendra C. Decile, Shri N. Giri, Kent E Pinkerton, William F. Walby, Jennifer M. Bratt, Harinder Grewal, Solomon B. Margolin, Edward S Schelegle

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Pirfenidone was administered to sensitized Brown Norway rats prior to a series of ovalbumin challenges. Airway hyperresponsiveness, inflammatory cell infiltration, mucin and collagen content, and the degree of epithelium and smooth muscle staining for TGF-β were examined in control, sensitized, and sensitized/challenged rats fed a normal diet or pirfenidone diet. Pirfenidone had no effect on airway hyperresponsiveness, but reduced distal bronchiolar cell infiltration and proximal and distal mucin content. Statistical analysis showed that the control group and sensitized/challenged pirfenidone diet group TGF-β staining intensity scores were not significantly different from isotype controls, but that the staining intensity scores for the sensitized/challenged normal diet group was significantly different from isotype controls. These results suggest that pirfenidone treatment is effective in reducing some of the components of acute inflammation induced by allergen challenge.

Original languageEnglish (US)
Pages (from-to)660-668
Number of pages9
JournalPulmonary Pharmacology and Therapeutics
Volume20
Issue number6
DOIs
StatePublished - Dec 2007

Keywords

  • Airway hyperresponsiveness
  • Asthma
  • Ovalbumin challenge
  • Pirfenidone
  • TGF-β

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology

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