Abstract
Both altered trace element metabolism and cigaret smoking have been proposed to be risk factors for cardiovascular disease (CVD). Thus, it is important to identify the mechanisms by which cigaret smoke alters trace element metabolism. In the present study, serum trace element concentrations were measured in 19 smokers and 13 nonsmokers. In parallel studies, data from rats treated with 50 mg of nicotine over a 21-d period tested the hypothesis that nicotine induced altered trace element metabolism observed in smokers. Serum Cu and Zn concentrations were significantly higher in smokers than in nonsmokers. Serum nicotine concentrations in rats were comparable to those observed in heavy smokers, but serum trace element concentrations were not significantly altered by nicotine treatment. Tissue trace element concentrations were also not markedly affected by nicotine; however, trace element ratios in liver, kidney, lung, and brain were significantly altered by nicotine treatment. In addition, nicotine-treatment resulted in significantly lower liver glutathione concentrations and higher Cu, Zn superoxide dismutase activity than in controls. These data show that a 50-mg infusion of nicotine over 21 d does not produce in rats the serum trace element abnormalities observed in cigaret smokers. However, nicotine did affect the trace element relationships between tissues as well as components of the free radical defense system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-109 |
| Number of pages | 13 |
| Journal | Biological Trace Element Research |
| Volume | 31 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 1991 |
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Keywords
- ascorbic acid
- copper
- glutathione
- nicotine
- superoxide dismutase
- Trace elements
- zinc
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry, medical
- Inorganic Chemistry
- Clinical Biochemistry
- Biochemistry
Cite this
Influence of nicotine on tissue trace element concentrations and tissue antioxidant defense. / Dubick, Michael A.; Keen, Carl L.
In: Biological Trace Element Research, Vol. 31, No. 2, 11.1991, p. 97-109.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of nicotine on tissue trace element concentrations and tissue antioxidant defense
AU - Dubick, Michael A.
AU - Keen, Carl L
PY - 1991/11
Y1 - 1991/11
N2 - Both altered trace element metabolism and cigaret smoking have been proposed to be risk factors for cardiovascular disease (CVD). Thus, it is important to identify the mechanisms by which cigaret smoke alters trace element metabolism. In the present study, serum trace element concentrations were measured in 19 smokers and 13 nonsmokers. In parallel studies, data from rats treated with 50 mg of nicotine over a 21-d period tested the hypothesis that nicotine induced altered trace element metabolism observed in smokers. Serum Cu and Zn concentrations were significantly higher in smokers than in nonsmokers. Serum nicotine concentrations in rats were comparable to those observed in heavy smokers, but serum trace element concentrations were not significantly altered by nicotine treatment. Tissue trace element concentrations were also not markedly affected by nicotine; however, trace element ratios in liver, kidney, lung, and brain were significantly altered by nicotine treatment. In addition, nicotine-treatment resulted in significantly lower liver glutathione concentrations and higher Cu, Zn superoxide dismutase activity than in controls. These data show that a 50-mg infusion of nicotine over 21 d does not produce in rats the serum trace element abnormalities observed in cigaret smokers. However, nicotine did affect the trace element relationships between tissues as well as components of the free radical defense system.
AB - Both altered trace element metabolism and cigaret smoking have been proposed to be risk factors for cardiovascular disease (CVD). Thus, it is important to identify the mechanisms by which cigaret smoke alters trace element metabolism. In the present study, serum trace element concentrations were measured in 19 smokers and 13 nonsmokers. In parallel studies, data from rats treated with 50 mg of nicotine over a 21-d period tested the hypothesis that nicotine induced altered trace element metabolism observed in smokers. Serum Cu and Zn concentrations were significantly higher in smokers than in nonsmokers. Serum nicotine concentrations in rats were comparable to those observed in heavy smokers, but serum trace element concentrations were not significantly altered by nicotine treatment. Tissue trace element concentrations were also not markedly affected by nicotine; however, trace element ratios in liver, kidney, lung, and brain were significantly altered by nicotine treatment. In addition, nicotine-treatment resulted in significantly lower liver glutathione concentrations and higher Cu, Zn superoxide dismutase activity than in controls. These data show that a 50-mg infusion of nicotine over 21 d does not produce in rats the serum trace element abnormalities observed in cigaret smokers. However, nicotine did affect the trace element relationships between tissues as well as components of the free radical defense system.
KW - ascorbic acid
KW - copper
KW - glutathione
KW - nicotine
KW - superoxide dismutase
KW - Trace elements
KW - zinc
UR - http://www.scopus.com/inward/record.url?scp=0026005529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026005529&partnerID=8YFLogxK
U2 - 10.1007/BF02990418
DO - 10.1007/BF02990418
M3 - Article
C2 - 9438031
AN - SCOPUS:0026005529
VL - 31
SP - 97
EP - 109
JO - Biological Trace Element Research
JF - Biological Trace Element Research
SN - 0163-4984
IS - 2
ER -