Influence of maternal zinc deficiency and irradiation on in utero development in mice

L. Hanna, J. Peters, L. Wiley, S. Zidenber-Cherr, Carl L Keen

Research output: Contribution to journalArticle

Abstract

It is well established that In mammals transitory Zn deficiency during embryogenesis can have a negative influence on fetal development. Similar in Zn deficiency, maternal exposure to low levels of ionizing radiation during the first day of pregnancy has been shown to negatively affect preimplantation embryo development, and higher doses of maternal irradiation during late stages of embryogenesis can result in malformations. Here we report the effect of transitory maternal Zn deprivation combined with low dose irradiation during embryogenesis on fetal outcome. Pregnant mice were dosed once with 0, .05, .1 or .25 Gy of γ-radiation the day after mating (GD0), or with 0 or .5 Gy on GD8. Mice irradiated on GD0 were either fed a low Zn diet (LznD, 0.4, ug Zn/g), for 48 h prior to mating through GD0 or GD0 and GD5and then switched to a control diet (50 ug Zn/R) through GD18. or they were fed the control throughout. The dams irradiated on GD8 were either fed the LZnD from GD0 through GD10 and then switched to the control, or they were fed the control throughout. Zn deprivation did not influente any of the maternal or embryonic/fetal parameters measured in the cohorts fed the LZnD through GD0. In contrast, mice led the LZnD through GD5 or GD10 had significantly lower mean maternal body weights, fewer live fetuses/litter, and a higher incidence of resorptions compared to controls. No influence of irradiation on GD0 or GD8 was observed for any of the parameters measured. These results show that despite a functional Zn deficiency in one cohort, the sensitivity of the conceptus to low-dose irradiation was not increased.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

Fingerprint

Embryonic Development
Zinc
irradiation
zinc
Mothers
Irradiation
embryogenesis
mice
Dosimetry
Nutrition
Maternal Deprivation
Diet
Maternal Exposure
Radiation Dosage
dosage
Fetal Development
Ionizing Radiation
conceptus
Mammals
Ionizing radiation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Hanna, L., Peters, J., Wiley, L., Zidenber-Cherr, S., & Keen, C. L. (1997). Influence of maternal zinc deficiency and irradiation on in utero development in mice. FASEB Journal, 11(3).

Influence of maternal zinc deficiency and irradiation on in utero development in mice. / Hanna, L.; Peters, J.; Wiley, L.; Zidenber-Cherr, S.; Keen, Carl L.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Hanna, L, Peters, J, Wiley, L, Zidenber-Cherr, S & Keen, CL 1997, 'Influence of maternal zinc deficiency and irradiation on in utero development in mice', FASEB Journal, vol. 11, no. 3.
Hanna L, Peters J, Wiley L, Zidenber-Cherr S, Keen CL. Influence of maternal zinc deficiency and irradiation on in utero development in mice. FASEB Journal. 1997;11(3).
Hanna, L. ; Peters, J. ; Wiley, L. ; Zidenber-Cherr, S. ; Keen, Carl L. / Influence of maternal zinc deficiency and irradiation on in utero development in mice. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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