Influence of iron and zinc status on cadmium accumulation in Bangladeshi women

Maria Kippler, Eva Charlotte Ekström, Bo Lönnerdal, Walter Goessler, Agneta Åkesson, Shams El Arifeen, Lars Åke Persson, Marie Vahter

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Cadmium is a widespread environmental contaminant present in food. The absorption in the intestine increases in individuals with low iron stores, but the effect of zinc deficiency is not clear. The aim of the present study was to assess the influence of iron and zinc status on cadmium accumulation in pregnant Bangladeshi women. We measured cadmium in urine from 890 women using inductively coupled plasma mass spectrometry (ICPMS). Further, we also measured ferritin and zinc in plasma. The median cadmium concentration in urine was 0.59 μg/L (adjusted to mean specific gravity of 1.012 g/mL). Analysis of covariance (ANCOVA) showed that urinary cadmium was associated with plasma ferritin and plasma zinc via a significant interaction between dichotomized plasma ferritin and plasma zinc. The analysis was adjusted for age and socioeconomic status. Women with low iron stores and adequate zinc status had significantly higher urinary cadmium compared to women with both adequate iron stores and zinc status. There was no difference in urinary cadmium between women with both low iron stores and zinc status compared to those with both adequate iron stores and zinc status. In conclusion, low iron stores were associated with increased cadmium accumulation, but only at adequate zinc status.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalToxicology and Applied Pharmacology
Volume222
Issue number2
DOIs
StatePublished - Jul 15 2007

Fingerprint

Cadmium
Zinc
Iron
Plasmas
Ferritins
Urine
Inductively coupled plasma mass spectrometry
Specific Gravity
Beam plasma interactions
Social Class
Density (specific gravity)
Intestines
Pregnant Women
Mass Spectrometry
Impurities
Food

Keywords

  • Bangladesh
  • Cadmium
  • Cadmium accumulation
  • Plasma ferritin
  • Plasma zinc

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Kippler, M., Ekström, E. C., Lönnerdal, B., Goessler, W., Åkesson, A., El Arifeen, S., ... Vahter, M. (2007). Influence of iron and zinc status on cadmium accumulation in Bangladeshi women. Toxicology and Applied Pharmacology, 222(2), 221-226. https://doi.org/10.1016/j.taap.2007.04.009

Influence of iron and zinc status on cadmium accumulation in Bangladeshi women. / Kippler, Maria; Ekström, Eva Charlotte; Lönnerdal, Bo; Goessler, Walter; Åkesson, Agneta; El Arifeen, Shams; Persson, Lars Åke; Vahter, Marie.

In: Toxicology and Applied Pharmacology, Vol. 222, No. 2, 15.07.2007, p. 221-226.

Research output: Contribution to journalArticle

Kippler, M, Ekström, EC, Lönnerdal, B, Goessler, W, Åkesson, A, El Arifeen, S, Persson, LÅ & Vahter, M 2007, 'Influence of iron and zinc status on cadmium accumulation in Bangladeshi women', Toxicology and Applied Pharmacology, vol. 222, no. 2, pp. 221-226. https://doi.org/10.1016/j.taap.2007.04.009
Kippler M, Ekström EC, Lönnerdal B, Goessler W, Åkesson A, El Arifeen S et al. Influence of iron and zinc status on cadmium accumulation in Bangladeshi women. Toxicology and Applied Pharmacology. 2007 Jul 15;222(2):221-226. https://doi.org/10.1016/j.taap.2007.04.009
Kippler, Maria ; Ekström, Eva Charlotte ; Lönnerdal, Bo ; Goessler, Walter ; Åkesson, Agneta ; El Arifeen, Shams ; Persson, Lars Åke ; Vahter, Marie. / Influence of iron and zinc status on cadmium accumulation in Bangladeshi women. In: Toxicology and Applied Pharmacology. 2007 ; Vol. 222, No. 2. pp. 221-226.
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